Correlation between histomorphometric findings on endomyocardial biopsy and clinical findings in idiopathic dilated cardiomyopathy.
Correlation between histomorphometric findings on endomyocardial biopsy and clinical findings in idiopathic dilated cardiomyopathy.
复制标题
心内膜心肌活检组织形态学结果与特发性扩张型心肌病临床结果之间的相关性。
DOI：
10.1016/0002-9149(89)90429-3
复制
发表时间：
1989
影响因子：
2.8
通讯作者：
F. Camerini
中科院分区：
文献类型：
--
作者：
P. Tanganelli;A. Di Lenarda;G. Bianciardi;A. Salvi;F. Silvestri;L. Mestroni;F. Camerini
Multivariate analysis was used to analyze the morphometric data of endomyocardial biopsies (area, perimeter and minor diameter) of myocardial cells obtained at light microscopy by a computerized approach with 16 clinical parameters and prognosis in 52 patients with idiopathic dilated cardiomyopathy. The best morphometric parameter was “area” (R2= 0.47). A positive correlation was found with age (p < 0.02), interval between first symptoms and diagnosis (p < 0.02), left ventricular end-diastolic volume (p < 0.02), cardiac index (p < 0.05) and echocardiographic end-diastolic diameter (p < 0.1). A negative correlation was found with prognosis (p < 0.02), ejection fraction (p < 0.02), shortening fraction (p < 0.05), echocardiographic end-systolic diameter (p < 0.06) and mitral regurgitation presence (p < 0.1). The parameters that provided no correlation were New York Heart Association class, left ventricular end-diastolic pressure, right atrial pressure, cardiothoracic ratio, presence or absence of heart failure, fever or alcohol intake. These findings suggest that endomyocardial biopsy may provide prognostic information and confirm clinical diagnosis.
