International Cooperative Study on the Relationship Between Dietary Factors and Blood Pressure: A Report from the Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study
International Cooperative Study on the Relationship Between Dietary Factors and Blood Pressure: A Report from the Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study
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饮食因素与血压关系的国际合作研究：心血管疾病与食物比较（CARDIAC）研究的报告
DOI：
10.1097/00005344-199000168-00018
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发表时间：
1990
影响因子：
3
通讯作者：
R. Horie
中科院分区：
文献类型：
--
作者：
Y. Yamori;Y. Nara;S. Mizushima;M. Mano;M. Sawamura;M. Kihara;R. Horie
为了调查饮食因素与血压（BP）和主要心血管疾病的流行病学关系，我们开展了国际心血管疾病和消化道比较合作研究（CARDIAC），迄今为止，该研究涉及20个国家的45个中心。从每个人群中随机选择100名男性和100名女性，年龄在50-54岁之间，进行血压测量，24小时尿液收集和血液检查。在Izumo CARDIAC中心集中分析了来自尿液和血液的饮食的各种生物标志物。在中心内多元回归分析中，体重指数（BMI）与血压呈强正相关且独立相关。尿镁（Mg）排泄量与血压呈负相关且独立相关。在多中心简单回归分析中，收缩压和舒张压与BMI呈显著相关（p < 0.01）和24小时尿钠（Na）排泄量（p < 0.005），与尿3-甲基组氨酸（3-MH）除以肌酐呈显著负相关与尿镁呈负相关（P <0.05）。因此，钠和BMI对血压有不利影响，而动物蛋白和镁的摄入量可能对血压有有益的影响。
To investigate the epidemiological relationship of dietary factors to blood pressure (BP) and major cardiovascular diseases, we carried out the International Cooperative Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study, which so far involves 45 centers in 20 countries. From each population, 100 men and 100 women aged 50–54 years were randomly selected for BP measurement, 24-h urine collection, and blood test. Various biological markers of diets from urine and blood were analyzed centrally in the Izumo CARDIAC center. In within-center multiple regression analyses, body mass index (BMI) was strongly positively and independently associated with BP. Urine magnesium (Mg) excretion was negatively and independently associated with BP. In cross-center simple regression analyses, systolic and diastolic BP showed significant correlations with BMI (p < 0.01) and 24-h urinary sodium (Na) excretion p < 0.005) in men and significant inverse correlations with urinary 3-methylhistidine (3-MH) divided by creatinine (p < 0.01 and p < 0.005, respectively) in men, and were inversely correlated with urinary Mg in women (p < 0.05). Therefore, Na and BMI adversely affect BP, whereas animal protein and Mg intakes may have beneficial influence on BP.