Glioma stem cells: turpis omen in nomen? (the evil in the name?)
Glioma stem cells: turpis omen in nomen? (the evil in the name?)
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DOI：
10.1111/joim.12254
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发表时间：
2014-07-01
影响因子：
11.1
通讯作者：
Vescovi, A. L.
中科院分区：
文献类型：
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作者：
Binda, E.;Reynolds, B. A.;Vescovi, A. L.
高级别胶质瘤仍然是无法治愈和致命的。随着胶质母细胞瘤(GB)形成、扩张、恢复和复发的干细胞的出现，胶质瘤肿瘤干细胞(GCSCs)的发现正在给这一领域带来革命性的变化。GCSCs为更准确地复制和研究GB病理生理学提供了前所未有的机会。这特别强调了我们有能力明确地识别、分离和研究确实符合GCSCs条件的细胞，将它们用作真正预测GBs及其对治疗剂的调节和反应的潜在模型。我们以躯体、神经和实体肿瘤干细胞(SCs)的主要发现为背景回顾这一概念，并考虑到表型SC可塑性的新现象。我们建议将这些领域的基本方法引入GCSC领域，从而使用于鉴定正常体细胞SCs的相同功能方法成为定义GCSC的最合适的方法。结合对正常成人神经发生的细胞和分子基础的了解，有望改进GCSCs和选择性标记的识别，以及开发创新的、更特异和有效的抗胶质瘤策略。
High-grade gliomas remain incurable and lethal. Through the availability of the stem-like cells responsible for glioblastoma (GB) formation, expansion, resilience and recurrence, the discovery of glioma cancer stem cells (GCSCs) is revolutionizing this field. GCSCs provide an unprecedented opportunity to reproduce and study GB pathophysiology more accurately. This critically emphasizes our ability to unambiguously identify, isolate and investigate cells that do qualify as GCSCs, to use them as a potential model that is truly predictive of GBs and of their regulation and response to therapeutic agents. We review this concept against the background of key findings on somatic, neural and solid tumour stem cells (SCs), also taking into account the emerging phenomenon of phenotypic SC plasticity. We suggest that basic approaches in these areas can be imported into the GCSC field, so that the same functional method used to identify normal somatic SCs becomes the most appropriate to define GCSCs. This, combined with knowledge of the cellular and molecular basis of normal adult neurogenesis, promises to improve the identification of GCSCs and of selective markers, as well as the development of innovative, more specific and efficacious antiglioma strategies.