SLC22A4 and RUNX1: identification of RA susceptible genes
SLC22A4 and RUNX1: identification of RA susceptible genes
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DOI：
10.1007/s00109-004-0547-y
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发表时间：
2004-06
期刊：
影响因子：
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通讯作者：
R. Yamada;S. Tokuhiro;X. Chang;Kazuhiko Yamamoto
中科院分区：
文献类型：
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作者：
R. Yamada;S. Tokuhiro;X. Chang;Kazuhiko Yamamoto
最近我们报道了SLC22A4和RUNX1与类风湿性关节炎（RA）相关。SLC22A4是一种具有未知生理功能的有机阳离子转运蛋白，RUNX1是一种血液学转录调节因子，已被证明与急性髓性白血病有关。提示RUNX1与RA的相关性可能与其调控SLC22A4的表达有关。由于SLC22A4的生理功能尚不清楚，因此需要进一步研究SLC22A4如何影响RA易感性。尽管RUNX1与RA的关联被鉴定为SLC 22A4的调节因子，但RUNX1可能是自身免疫中的关键分子，因为已报道其与系统性红斑狼疮和银屑病这两种其他自身免疫性疾病相关。
Recently we reported that SLC22A4 and RUNX1 are associated with rheumatoid arthritis (RA). SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for acute myelogenic leukemia. It is suggested that the association of RUNX1 with RA is due to its regulation of expression of SLC22A4. Because the physiological function of SLC22A4 is still unclear, further investigation is needed into how SLC22A4 affects RA susceptibility. Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases.