Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease.
Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease.
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DOI：
10.3904/kjim.2017.030
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Rhee CK
中科院分区：
文献类型：
--
作者：
Ban WH;Kang HH;Kim IK;Ha JH;Joo H;Lee JM;Lim JU;Lee SH;Rhee CK
一些研究已经确定核因子红系相关因子2(NRF2)在慢性阻塞性肺疾病(COPD)的发生发展中的作用。然而，血浆Nrf2水平与与COPD状态相关的全身炎症程度之间的关系尚不清楚。被诊断为慢性阻塞性肺疾病的患者是在2009年7月至2012年5月期间从韩国天主教大学圣保罗医院招募的。根据首发症状的严重程度将患者分为两组，COPD稳定组(n=25)和COPD加重组(n=30)。17例作为对照组(n=17)。检测血浆Nrf2和其他全身炎症标志物，包括白介素6(IL-6)、表面活性蛋白D(SP-D)和C反应蛋白(CRP)。收集包括肺功能检测结果在内的临床资料，分析生物标志物水平与临床参数的关系。血浆NRF2和C反应蛋白水平随着炎症状态的增加而显著升高(对照组与COPD稳定组与COPD恶化组)(p=0.002，p<；0.001)。其他全身炎症标志物(IL-6、SP-D)也有类似的趋势，但差异不明显。此外，我们观察到血浆NRF2水平与1s用力呼气量(FEV1)(r=-0.339，p=0.015)和用力呼气比(FEV1/用力肺活量)(r=-0.342，p=0.014)呈负相关。然而，C反应蛋白水平与任何测量参数均无相关性。COPD患者血浆Nrf2水平随着疾病严重程度和全身炎症程度的加重而逐渐升高。
Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD status remains unclear. Patients diagnosed with COPD were recruited from St. Paul’s Hospital, The Catholic University of Korea, between July 2009 and May 2012. Patients were classified into two groups according to the severity of their symptoms on initial presentation, a COPD-stable group (n = 25) and a COPD-exacerbation group (n = 30). Seventeen patients were enrolled as a control group (n = 17). The plasma levels of Nrf2 and other systemic inf lammatory biomarkers, including interleukin 6 (IL-6), surfactant protein D (SP-D), and C-reactive protein (CRP), were measured. We collected clinical data including pulmonary function test results, and analyzed the relationships between the biomarker levels and the clinical parameters. Plasma Nrf2 and CRP levels significantly increased in a stepwise manner with an increase in inflammatory status (control vs. COPD-stable vs. COPD-exacerbation) (p = 0.002, p < 0.001). Other biomarkers of systemic inflammation (IL-6, SP-D) exhibited similar tendencies, but significant differences were not apparent. Furthermore, we observed negative correlations between the plasma level of Nrf2 and both the forced expiratory volume in 1 second (FEV1) (r = –0.339, p = 0.015) and the forced expiratory ratio (FEV1/forced vital capacity [FVC]) (r = –0.342, p = 0.014). However, CRP level was not correlated with any measured parameter. Plasma Nrf2 levels gradually increased in line with disease severity and the extent of systemic inflammation in patients with COPD.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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作者：
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发表时间：
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影响因子：
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作者：
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影响因子：
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作者：
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