The prevalence of autistic spectrum disorder in children surveyed in a tertiary care epilepsy clinic
The prevalence of autistic spectrum disorder in children surveyed in a tertiary care epilepsy clinic
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DOI：
10.1111/j.1528-1167.2005.00343.x
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发表时间：
2005-12-01
期刊：
影响因子：
5.6
通讯作者：
Weiss, SK
中科院分区：
文献类型：
--
作者：
Clarke, DF;Roberts, W;Weiss, SK
有充分证据表明，患有自闭症谱系障碍 (ASD) 的儿童癫痫发作的患病率较高；然而，尚未开展研究来评估癫痫儿童中 ASD 的患病率。这种合并症的定义很重要，因为对一些 ASD 儿童的早期诊断和干预已被证明可以改善预后。方法：使用经过验证的自闭症筛查问卷 (ASQ) 对在三级护理癫痫诊所就诊的癫痫儿童进行评估。此外，还要求询问有关睡眠相关疾病、行为、癫痫特征、抗癫痫药物和体重指数（BMI）的问题。然后尝试确定所确定的因素与自闭症谱系障碍之间是否存在相关性。结果：在返回的 107 份问卷中，97 份 ASQ 已正确完成并在本研究中使用。大约 32% 的儿童符合 ASQ 患有 ASD 的标准。大多数儿童之前并未被诊断出来。风险较高的人行为最差，白天嗜睡（p < 0.01）。有 ASD 风险的儿童癫痫发作也较早发生（大约 2 岁）。结论：虽然需要进行验证性诊断评估，但这项基于问卷的研究表明，癫痫儿童患 ASD 的风险更大，并说明需要更多的临床警惕。这些儿童的行为困难和白天嗜睡可能会影响他们的学习能力。有趣的是，在高风险人群中确定的癫痫发作年龄与在一些患有自闭症谱系障碍（ASD）的儿童中确定的回归的大致年龄相对应。
It is well documented that children with autistic spectrum disorder (ASD) have an increased prevalence of seizures; however, studies have not been done to evaluate the prevalence of ASD in children with epilepsy. This comorbidity is important to define as early diagnosis and intervention in some children with ASD has been shown to improve outcome.Method: Children with epilepsy seen in a tertiary care epilepsy clinic were evaluated using validated autism screening questionnaires (ASQ). In addition, questions about sleep-related disorders, behavior, seizure characteristics, antiepileptic agents, and body mass index (BMI) were requested. An attempt was then made to determine if there was a correlation between the factors identified and ASD.Results: Of the 107 questionnaires returned, 97 ASQ's were properly completed and used in this study. Approximately 32% of children fit the ASQ criteria for having ASD. Most children had not been previously diagnosed. Worst behavior and daytime sleepiness was seen in those at greater risk (p < 0.01). Seizures also occurred earlier (approximately 2 years) in children at risk of having ASD.Conclusion: Though confirmatory diagnostic evaluations are needed, this questionnaire-based study suggests that children with epilepsy are at greater risk of having ASD, and illustrates the need for more clinical vigilance. Behavioral difficulties and daytime sleepiness identified in these children could potentially affect their ability to learn. It is of interest that the age of seizure onset identified in those at greater risk corresponds with the approximate age of regression identified in some children with ASD.