Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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DOI：
10.1038/36285
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发表时间：
1997-11-06
期刊：
影响因子：
64.8
通讯作者：
Nabeshima, Y
中科院分区：
文献类型：
--
作者：
Kuroo, M;Matsumura, Y;Nabeshima, Y
一种名为klotho的新基因已经被鉴定出来，它与抑制几种衰老表型有关。小鼠klotho基因表达的缺陷会导致一种类似于人类衰老的综合征，包括寿命缩短、不育、动脉硬化、皮肤萎缩、骨质疏松和肺气肿。该基因编码与β-葡糖苷酶具有序列相似性的膜蛋白。klotho基因产物可能作为调节体内衰老和年龄相关疾病发病率的信号通路的一部分发挥作用。
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, Including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the B-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity In age-related diseases.