Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.
Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.
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DOI：
10.1038/icb.2011.76
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发表时间：
2012-07
影响因子：
4
通讯作者：
Hayes, Sandra M.
中科院分区：
文献类型：
--
作者：
Samuelson, Elizabeth M.;Laird, Renee M.;Maue, Alexander C.;Rochford, Rosemary;Hayes, Sandra M.
Blk was identified two decades ago as a B cell-specific member of the Src family of tyrosine kinases. Recent studies, however, have discovered that Blk is expressed in many cell types outside of the B lineage, including early thymic precursors, IL-17-producing γδ T cells and pancreatic β-cells. In light of these recent discoveries, we performed a more comprehensive analysis of Blk expression patterns in hematopoietic cells and found that Blk is differentially expressed in mature B cell subsets, with marginal zone (MZ) B cells expressing high levels, B1 B cells expressing intermediate to high levels, and follicular (FO) B cells expressing low levels of Blk. To determine whether these differences in Blk expression levels reflected differential requirements for Blk in MZ, B1 and FO B cell development, we analyzed the effects of reducing and eliminating Blk expression on B cell development. We report that both Blk-haploinsufficiency and Blk-deficiency impaired the generation of MZ B cells. Moreover, although there were fewer MZ B cells in Blk+/− and Blk−/− mice compared to Blk+/+ mice, Blk mutant MZ B cells were hyper-responsive to B cell receptor stimulation, both in vitro and in vivo. Thus, this study has revealed a previously unappreciated role for Blk in the development and activation of MZ B cells.
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影响因子：
20.3
作者：
Chen, Yuhong;Yu, Mei;Wang, Demin
通讯作者：
Wang, Demin
影响因子：
30.5
作者：
Guinamard, R;Okigaki, M;Ravetch, JV
通讯作者：
Ravetch, JV
DOI：
10.1084/jem.186.11.1923
发表时间：
1997-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Inaoki M;Sato S;Weintraub BC;Goodnow CC;Tedder TF
通讯作者：
Tedder TF
影响因子：
32.4
作者：
CYSTER, JG;GOODNOW, CC
通讯作者：
GOODNOW, CC
DOI：
10.1073/pnas.88.16.7410
发表时间：
1991-08-01
影响因子：
11.1
作者：
BURKHARDT, AL;BRUNSWICK, M;MOND, JJ
通讯作者：
MOND, JJ