Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy
Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy
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DOI：
10.1021/ja0680257
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发表时间：
2007-03-07
影响因子：
15
通讯作者：
Prasad, Paras N.
中科院分区：
文献类型：
--
作者：
Kim, Sehoon;Ohulchanskyy, Tymish Y.;Prasad, Paras N.
我们报道了用于双光子光动力治疗的能量转移有机修饰的二氧化硅纳米颗粒。这些纳米颗粒共封装作为能量上转换供体的双光子荧光染料纳米聚集体和作为受体的光敏PDT药物。它们结合了联合收割机的两个特点：（i）一种新型双光子染料的聚集增强的双光子吸收和发射性质，以及（ii）该纳米聚集体与光敏剂2-去乙烯基-2-（1-己氧基乙基）焦脱镁叶绿酸之间的纳米级荧光共振能量转移。共包封纳米颗粒的稳定水性分散体（直径
We report energy-transferring organically modified silica nanoparticles for two-photon photodynamic therapy. These nanoparticles co-encapsulate two-photon fluorescent dye nanoaggregates as an energy up-converting donor and a photosensitizing PDT drug as an acceptor. They combine two features: (i) aggregation-enhanced two-photon absorption and emission properties of a novel two-photon dye and (ii) nanoscopic fluorescence resonance energy transfer between this nanoaggregate and a photosensitizer, 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide. Stable aqueous dispersions of the co-encapsulating nanoparticles (diameter