A New Phenylpropane Glycoside from the Rhizome of Sparganium stoloniferum
A New Phenylpropane Glycoside from the Rhizome of Sparganium stoloniferum
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DOI：
10.1007/s12272-010-0404-1
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发表时间：
2010-04-01
影响因子：
6.7
通讯作者：
Lee, Kang Ro
中科院分区：
文献类型：
--
作者：
Lee, Seung Young;Choi, Sang Un;Lee, Kang Ro
三棱甲醇提取物的纯化哈米尔从黑三棱科植物中分离得到一个新的苯丙素苷（7）和已知的酚类化合物（1 - 6和8 - 13）。7的结构解析基于1D-和2D-NMR光谱数据分析，为β-D-（6-O-反式-阿魏酰）呋喃果糖基-α-D-O-吡喃葡萄糖苷。化合物1 - 6和8 - 13通过光谱学进行了解析，并通过与报道数据的比较进行了确认：24-亚甲基环木菠萝烷醇（1）、对羟基苯甲醛（2）、阿魏酸（3）、对香豆酸（4）、香草酸（5）、β-D-（1-O-乙酰基-3-O-反式-阿魏酸酰基）呋喃果糖基-α-D-2 '，4'，6 '。O-triacetyglucopyranoisde（6），beta-D-（1-O-acetyl-3，6-O-trans-diferuloyl）fructofuranosyl-alpha-D-2'，4'，6'. - O-三乙酰基吡喃葡萄糖苷（8）、羟基酪醇乙酸酯（9）、羟基酪醇（10）、异鼠李素-3-O-芸香糖苷（11）、正丁基-α-D-呋喃果糖苷（12）和正丁基-β-D-吡喃果糖苷（13）。化合物3和9-13为首次从该植物中分离得到。使用磺酰罗丹明B生物测定法在体外测试分离的化合物对四种人肿瘤细胞系的细胞毒性。
The purification of the MeOH extract from the rhizome of Sparganium stoloniferum Buch.-Hamil. (Sparganiaceae) using column chromatography furnished one new phenylpropanoid glycoside (7) and known phenolic compounds (1-6, and 8-13). The structural elucidation of 7 was based on 1D- and 2D-NMR spectroscopic data analysis to be beta-D-(6-O-trans-feruloyl) fructofuranosyl-alpha-D-O-glucopyranoside. Compounds 1-6, and 8-13 were elucidated by spectroscopy and confirmed by comparison with reported data; 24-methylenecycloartanol (1), phydroxybenzaldehyde (2), ferulic acid (3), p-coumaric acid (4), vanillic acid (5), beta-D-(1-O-acetyl-3-O-trans-feruloyl)fructofuranosy-alpha-D-2',4',6'.-O-triacetyglucopyranoisde (6), beta-D-(1-O-acetyl-3,6-O-trans-diferuloyl)fructofuranosyl-alpha-D-2',4',6'.-O-triacetylglucopyranoisde (8), hydroxytyrosol acetate (9), hydroxytyrosol (10), isorhamnetin-3-O-rutinoside (11), n-butyl-alpha-D-fructofuranoside (12), and n-butyl-beta-D-fructopyranoside (13). Compounds 3 and 9-13 were isolated for the first time from this plant. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.