No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease - Results from the cardiovascular health study
No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease - Results from the cardiovascular health study
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DOI：
10.1055/s-0037-1613057
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发表时间：
2002-04-01
影响因子：
6.7
通讯作者：
Tracy, RP
中科院分区：
文献类型：
--
作者：
Smiles, AM;Jenny, NS;Tracy, RP
Prothrombin is a key factor in blood clotting. a process intimately involved in thrombotic disease. We assessed prothrombin levels and G20210A genotype in a case-control study within the Cardiovascular Health Study. (bases included angina, myocardial infarction. stroke, and the presence of MRI-detectable infarcts (n approximate to 250 each). Population-based controls free of clinical cardiovascular disease (CVD) (n approximate to 500) and a subset fret, of clinical and subclinical CVD (n approximate to 250) were used for comparison. The 20210 A allele. frequency 2.9%, was associated with higher mean prothrombin levels: 166.3 vs, 139.5 mug/ml (P
