Use of HPV testing in cervical cancer screening services in Mexico, 2008-2018: a nationwide database study
Use of HPV testing in cervical cancer screening services in Mexico, 2008-2018: a nationwide database study
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DOI：
10.21149/9891
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发表时间：
2018-12-01
期刊：
影响因子：
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通讯作者：
Lazcano-Ponce, Eduardo
中科院分区：
文献类型：
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作者：
Hurtado-Salgado, Erika;Ortiz-Panozo, Eduardo;Lazcano-Ponce, Eduardo
目标。目的描述一项旨在评估墨西哥国家癌症筛查计划(NCSP)中基于高危HPV(HrHPV)的筛查和宫颈细胞学作为初步筛查方法与传统宫颈细胞学作为主要筛查方法检测2+宫颈上皮内瘤变的方法。材料和方法。我们将使用来自墨西哥妇女癌症信息系统的2008年至2018年关于宫颈癌的信息。该数据库包括细胞学结果、组织病理学和/或治疗阴道镜的诊断确认。然后，我们将对大约1500万人乳头状瘤病毒进行统计分析。结果。我们将评估基于hrHPV的筛查作为NCSP的一部分的整体性能，并在现实条件下将基于hrHPV的筛查与基于细胞学的筛查进行比较。为了保证hrHPV与细胞学分类和传统细胞学之间的公正比较，我们将使用倾向评分匹配。结论。决策者可以使用我们的结果来确定NCSP流程中有待改进的领域。
Objective. To describe the methods of a study aimed at evaluating high risk-HPV (hrHPV)-based screening and cervical cytology as triage compared to conventional cervical cytology as primary screening in the detection of grade 2+ cervical intraepithelial neoplasia in the National Cancer Screening Program (NCSP) of Mexico. Materials and methods. We will use information originated from the Womens Cancer Information System of Mexico regarding cervical cancer from 2008 to 2018. The database includes cytology results, diagnostic confirmation by histopathology and/or treatment colposcopy.We will then carry out statistical analyses on approximately 15 million hrHPV. Results. We will evaluate the overall performance of hrHPV-based screening as part of the NCSP and compare hrHPV-based to cytology-based screening under real-life conditions. To guarantee an unbiased comparison between hrHPV with cytology triage and conventional cytology we will use propensity score matching. Conclusion. Decision makers may use our results to identify areas of opportunity for improvement in NCSP processes.