Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
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饮食N-3脂肪酸，α-生育酚，锌，维生素D，维生素C和β-胡萝卜素与日本与年龄有关的黄斑变性有关。
DOI：
10.1038/srep20723
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发表时间：
2016-02-05
影响因子：
4.6
通讯作者：
Yanagi Y
中科院分区：
文献类型：
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作者：
Aoki A;Inoue M;Nguyen E;Obata R;Kadonosono K;Shinkai S;Hashimoto H;Sasaki S;Yanagi Y
本病例对照研究报告了日本营养素摄入与新生血管性年龄相关性黄斑变性（AMD）之间的关系。采用饮食史问卷调查对来自两所大学医院的161例新生血管性AMD患者和来自一项队列研究的369例基于人群的对照受试者的营养摄入进行了评估，该问卷调查要求受访者回忆前一个月内58种食物的通常摄入量。能量调整的营养素摄入值进行了比较组之间。Logistic回归分析用于估计经吸烟史、年龄、性别、慢性病史、补充剂使用和饮酒调整后的比值比（OR）和95% CI。Logistic回归分析显示n-3脂肪酸、α-生育酚、锌、维生素D、维生素C和β-胡萝卜素摄入量低与新生血管性AMD的发生有关（n-3脂肪酸趋势P < 0.0001，α-生育酚趋势P < 0.0001，锌趋势P < 0.0001，维生素D趋势P = 0.002，维生素C趋势P = 0.04，β-胡萝卜素趋势P = 0.0004）。视黄醇或隐黄质摄入与新生血管性AMD无相关性（P = 0.67，0.06）。
This case-control study reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) in Japan. The nutrient intake of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects from a cohort study was assessed using a brief-type self-administered questionnaire on diet history, which required respondent recall of the usual intake of 58 foods during the preceding month. Energy-adjusted nutrient intake values were compared between the groups. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% CIs adjusted for smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption. Logistic regression analysis demonstrated that low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD (Trend P < 0.0001 for n-3 fatty acid, Trend P < 0.0001 for α-tocopherol, Trend P < 0.0001 for zinc, Trend P = 0.002 for vitamin D, Trend P = 0.04 for vitamin C, Trend P = 0.0004 for β-carotene). There was no association with retinol or cryptoxanthin intake and neovascular AMD (P = 0.67, 0.06).