INVARIANTS AND NONINVARIANTS IN THE CONCEPT OF INTERDEPENDENT EFFECTS
INVARIANTS AND NONINVARIANTS IN THE CONCEPT OF INTERDEPENDENT EFFECTS
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DOI：
10.5271/sjweh.1945
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发表时间：
1988-04-01
影响因子：
6.3
通讯作者：
POOLE, C
中科院分区：
文献类型：
--
作者：
GREENLAND, S;POOLE, C
相互依赖效应概念中的不变量和非不变量。扫描J工作环境健康14（1988）125-129。在他的两个出版物[因果和预防相互依存：基本原则。Scand J Work Environ Health 8（1982）159-168和Theoretical Epidermiology，John Wiley and Sons，纽约，NY 1985]，Miettinen提出了涉及二元暴露指标和结果的效应的因果和预防相互依赖性的基本定义。本文表明，识别的相互依赖性使用Miettinen的定义不同的选择的参考类别的曝光。特别是，Miettinen的协同作用和拮抗作用的概念在暴露重新编码下不是不变的。它还表明，当这两个曝光影响风险在一些个人，影响将出现相互依赖的一些选择下的参照。在确定性的情况下，联合效应的不变属性可以通过响应类型的等价类的形成来识别。在随机的情况下，不变的属性可以通过单个危险的平均值来识别，而不是风险。在这两种情况下，风险或利率差异的可加性成为影响独立性的基本标准。
Invariants and noninvariants in the concept of interdependent effects. Scan J Work Environ Health 14 (1988) 125-129. In two of his publications [Causal and preventive interdependence: Elementary principles. Scand J Work Environ Health 8 (1982) 159-168 and Theoretical Epidermiology, John Wiley and Sons, New York, NY 1985], Miettinen put forth basic definitions of causal and preventive interdependence of effects involving binary exposure indicators and outcomes. This paper shows that the identification of interdependence using Miettinen''s definitions varies with the choice of the reference categories for the exposures. In particular, Miettinen''s concepts of synergism and antagonism are not invariant under exposure recoding. It is also shown that, when both exposures affect risk in some individuals, the effects will appear interdependent under some choice of referent. In the deterministic case, invariant properties of joint effects may be identified through the formation of equivalence classes of response types. In the stochastic case, invariant properties may be identified through the averaging of individual hazards, rather than risks. In both cases, additivity of risk or rate differences emerges as an elementary criterion for the independence of effects.