Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats
Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats
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DOI：
10.1002/ptr.2452
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发表时间：
2008-07-01
影响因子：
7.2
通讯作者：
Bao-feng, Yang
中科院分区：
文献类型：
--
作者：
Hong-li, Sun;Lei, Li;Bao-feng, Yang
氧化苦参碱已被证明具有多种药理作用。越来越多的证据表明氧化苦参碱可能对心血管系统发挥保护作用。该研究旨在探讨氧化苦参碱对抗心肌缺血损伤的可能作用以及作为潜在机制的几个相关信号通路。在因永久结扎左冠状动脉前降支而导致急性心肌梗死的大鼠模型中研究了氧化苦参碱的保护特性。结果表明，氧化苦参碱可减轻缺血期间的心肌损伤，这是通过保护心肌细胞免于凋亡而实现的。氧化苦参碱的有益作用可能是通过抑制脂质过氧化（MDA 产生）、增加内源性抗氧化活性（SOD）、激活生存信号分子（Bcl-2）以及减少凋亡介质（Fas）和细胞内 Ca2+ 超载来介导的。版权所有 (c) 2008 John Wiley & Sons, Ltd.
Oxymatrine has been demonstrated to have a variety of pharmacological actions. Accumulating evidence indicates that oxymatrine may exert a protective effect on the cardiovascular system. The study was designed to explore the possible role of oxymatrine against myocardial ischemic damage and several related signaling pathways as potential mechanisms. The protective properties of oxymatrine were studied in a rat model of acute myocardial infarction due to permanent ligation of the left anterior descending coronary artery. The results showed that administration of oxymatrine relieved myocardial injuries during ischernia, and this was achieved by protecting cardiomyocytes from apoptotic death. The beneficial effects of oxymatrine were likely mediated by an inhibition of lipid peroxidation (MDA production) and an increase in endogenous antioxidant activity (SOD), activation of the survival signaling molecule (Bcl-2), and a reduction of apoptotic mediator (Fas) and intracellular Ca2+ overload. Copyright (c) 2008 John Wiley & Sons, Ltd.