MicroRNAs as Regulators of Neural Stem Cell-Related Pathways in Glioblastoma Multiforme
MicroRNAs as Regulators of Neural Stem Cell-Related Pathways in Glioblastoma Multiforme
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DOI：
10.1007/s12035-011-8196-y
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发表时间：
2011-12-01
影响因子：
5.1
通讯作者：
Mira, Helena
中科院分区：
文献类型：
--
作者：
Gonzalez-Gomez, Pilar;Sanchez, Pilar;Mira, Helena
MicroRNA是内源性非编码小RNA，已被描述为基因表达的高度保守调节因子。它们与癌症以及神经发育和干细胞功能的调节有关。最近的研究表明，癌症干细胞（CSC）的一个小亚群有能力重新填充实体瘤，如胶质母细胞瘤（GBM），推动恶性进展，并介导放射性和化学抗性。GBM衍生的CSC与神经干细胞（NSC）共享自我更新和多能性的基本干细胞特性，并且可以由miRNA调节。本文就miRNAs在GBM发育中的作用，特别是对GBM-CSC的调控进行综述。我们提出了一个清单的miRNA，可以作为GBM的分子分类器和/或作为有前途的治疗目标，这样的脑肿瘤。
MicroRNAs are endogenous non-coding small RNAs that have been described as highly conserved regulators of gene expression. They are involved in cancer and in the regulation of neural development and stem cell function. Recent studies suggest that a small subpopulation of cancer stem cells (CSCs) has the capacity to repopulate solid tumours such as glioblastoma (GBM), drive malignant progression and mediate radio- and chemoresistance. GBM-derived CSCs share the fundamental stem cell properties of self-renewal and multipotency with neural stem cells (NSCs) and may be regulated by miRNAs. In this review, we will summarize the current knowledge regarding the role of miRNAs in GBM development with a focus on the regulation of GBM-CSCs. We propose a list of miRNAs that could serve as molecular classifiers for GBMs and/or as promising therapeutic targets for such brain tumours.