Preparation and properties of a highly elastic galactomannan- poly (acrylamide- N, N-bis (acryloyl) cysteamine) hydrogel with reductive stimuli-responsive degradable properties
Preparation and properties of a highly elastic galactomannan- poly (acrylamide- N, N-bis (acryloyl) cysteamine) hydrogel with reductive stimuli-responsive degradable properties
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DOI：
10.1016/j.carbpol.2019.115690
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发表时间：
2020-03-01
影响因子：
11.2
通讯作者：
Duan, Jiufang
中科院分区：
文献类型：
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作者：
Gao, Yuxue;Zong, Shiyu;Duan, Jiufang
以半乳甘露聚糖（GA）、N，N-双丙烯酰半胱胺（BAC）和丙烯酰胺为原料，采用水溶液接枝聚合法合成了氧化还原响应性可降解高弹性半乳甘露聚糖水凝胶。利用傅里叶变换红外光谱（FTIR）、扫描电镜（SEM）、紫外光谱和差示扫描量热仪（DSC）等手段对水凝胶的微观结构、降解性能和力学性能进行了研究。通过调节GA的含量可以改善水凝胶的力学性能。连续循环压缩实验表明，该水凝胶在60%、70%、80%的应变下不破裂，并能迅速恢复到原来的形状。水凝胶的降解速率和药物释放速率可以通过还原剂浓度和还原时间来调节。这些水凝胶拓宽了GA的应用范围，并且可以调节广泛的机械、降解和释放性能，因此在药物载体、组织工程支架、细胞外基质等领域具有潜在的应用。
An oxidation-reduction responsive degradable highly elastic galactomannan hydrogel was synthesized from galactomannan (GA), N,N-bis (acryloyl) cysteamine (BAC) and acrylamide by grafting polymerization in aqueous solution. The microstructure, degradability and mechanical properties of the hydrogels were emphatically investigated using Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), ultraviolet spectroscopy and differential scanning calorimetry (DSC). The mechanical properties of hydrogels can be improved by adjusting the content of GA. Continuous cyclic compression tests showed that the hydrogel did not rupture under 60 %,70 %,80 % strain and quickly recovered to its original shape. The degradation rate and drug release rate of hydrogel can be adjusted by the concentration of the reductant and the reduction time. These hydrogels broaden the scope of application of GA and can be tuned with a broad range of mechanical, degradation and release properties and therefore hold potential applications in drug carriers, tissue engineering scaffolds, extracellular matrix and other fields.