THE CODON ADAPTATION INDEX - A MEASURE OF DIRECTIONAL SYNONYMOUS CODON USAGE BIAS, AND ITS POTENTIAL APPLICATIONS
THE CODON ADAPTATION INDEX - A MEASURE OF DIRECTIONAL SYNONYMOUS CODON USAGE BIAS, AND ITS POTENTIAL APPLICATIONS
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DOI：
10.1093/nar/15.3.1281
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发表时间：
1987-02-11
影响因子：
14.9
通讯作者：
LI, WH
中科院分区：
文献类型：
--
作者：
SHARP, PM;LI, WH
一个简单的，有效的措施同义密码子的使用偏好，密码子适应指数，详细。该指数使用一组来自一个物种的高表达基因来评估每个密码子的相对优点，并根据该基因中所有密码子的使用频率计算基因的得分。该指数评估了选择在塑造密码子使用模式方面的有效程度。在这方面，它可用于预测基因的表达水平，用于评估病毒基因对其宿主的适应性，以及用于比较不同生物体中的密码子使用。该指数还可以给出异源基因表达可能成功的近似指示。
A simple, effective measure of synonymous codon usage bias, the Codon Adaptation Index, is detailed. The index uses a reference set of highly expressed genes from a species to assess the relative merits of each codon, and a score for a gene is calculated from the frequency of use of all codons in that gene. The index assesses the extent to which selection has been effective in moulding the pattern of codon usage. In that respect it is useful for predicting the level of expression of a gene, for assessing the adaptation of viral genes to their hosts, and for making comparisons of codon usage in different organisms. The index may also give an approximate indication of the likely success of heterologous gene expression.