β-Carbon Elimination from Cyclobutanols: A Clean Access to Alkylrhodium Intermediates Bearing a Quaternary Stereogenic Center
β-Carbon Elimination from Cyclobutanols: A Clean Access to Alkylrhodium Intermediates Bearing a Quaternary Stereogenic Center
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DOI：
10.1055/s-0030-1259536
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发表时间：
2011-03-01
期刊：
影响因子：
2
通讯作者：
Seiser, Tobias
中科院分区：
文献类型：
--
作者：
Cramer, Nicolai;Seiser, Tobias
C-C键的催化活化具有显著的生态和经济优势。在这个帐户中，我们描述了我们的结果对称取代叔环丁醇的对映选择性C-C活化。随后的下游反应得到的烷基铑中间体产生了广泛的合成通用产品轴承具有优异的对映选择性的全碳季立体中心。
The catalytic activation of C-C bonds bears significant ecological and economical advantages. In this account we describe our results for an enantioselective C-C activation of symmetrically substituted tert-cyclobutanols. Subsequent downstream reactions of the obtained alkylrhodium intermediate give rise to a wide range of synthetically versatile products bearing all-carbon quaternary stereogenic centers with excellent enantioselectivities.