Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats
Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats
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DOI：
10.1152/ajplung.00105.2002
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发表时间：
2003-01-01
影响因子：
4.9
通讯作者：
Hirst, SJ
中科院分区：
文献类型：
--
作者：
Moir, LM;Leung, SY;Hirst, SJ
反复卵清蛋白（OA）或生理盐水暴露致敏的布朗挪威大鼠的激动剂反应性，气道平滑肌（ASM）的内容，并在小细支气管收缩蛋白的表达在24小时，7天和35天后的挑战。OA在24 h时增加ASM含量（与生理盐水相比P < 0.05），7天后消退。24 h时，OA使细支气管中卡巴胆碱、KCl和4-β-佛波醇12，13-二丁酸酯的最大张力（Tmax）增加（P < 0.05），但校正ASM后消除。在第7天不存在Tmax差异。而在35天时，Tmax增加（P <0.05），
Repeated ovalbumin (OA) or saline exposure of sensitized Brown Norway rats was examined on agonist reactivity, airway smooth muscle (ASM) content, and contractile protein expression in small bronchioles at 24 h, 7 days, and 35 days after challenge. OA increased ASM content (P < 0.05 vs. saline) at 24 h, which resolved by 7 days. Maximum developed tension (T-max) to carbachol, KCl, and 4-beta-phorbol 12,13-dibutyrate was increased (P < 0.05) by OA in bronchioles at 24 h but was abrogated after correction for ASM. Differences in Tmax were not present at 7 days. In contrast, at 35 days, T-max was increased (P