Automated Segmentation of Hippocampal Subfields in Drug-Naive Patients with Alzheimer Disease
Automated Segmentation of Hippocampal Subfields in Drug-Naive Patients with Alzheimer Disease
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DOI：
10.3174/ajnr.a3293
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发表时间：
2013-04-01
影响因子：
3.5
通讯作者：
Lee, C. U.
中科院分区：
文献类型：
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作者：
Lim, H. K.;Hong, S. C.;Lee, C. U.
背景和目的：虽然已经开发了一些自动海马子场分割方法，但还没有研究阿尔茨海默病的诊断对海马子场体积的影响。本研究的目的是通过使用自动海马子区分割技术来研究未用药的AD受试者和健康老年人controls.MATERIALS和METHODS之间海马子区体积的差异：31名未用药的AD受试者和33名组匹配的健康对照受试者进行3 T MR成像，测量海马子区体积并在组间进行比较。与健康受试者相比，AD受试者的前下托、下托、CA 2 -3和CA 4 DG的体积显著较小（未校正，P <0.001）。此外，我们发现显着的正相关性之间的前下托和下托体积和MMSE-K和CERAD-K口头延迟回忆分数在AD group.CONCLUSIONS：我们不知道以前的自动海马子字段分割AD的成像研究。海马前下托、下托和CA 2 -3的这些结构变化可能是海马功能障碍的潜在神经生物学机制及其与AD中言语延迟回忆障碍的相关性的核心。
BACKGROUND AND PURPOSE: Although a few automated hippocampal subfield segmentation methods have been developed, there is no study on the effects of the diagnosis of Alzheimer disease on the hippocampal subfield volume with in vivo MR imaging. The aim of this study was to investigate hippocampal subfield volume differences between drug-naive subjects with AD and healthy elderly controls by using an automated hippocampal subfield segmentation technique.MATERIALS AND METHODS: Thirty-one drug-naive subjects with AD and 33 group-matched healthy control subjects underwent 3T MR imaging, and hippocampal subfield volume was measured and compared between the groups.RESULTS: Subjects with AD had significantly smaller volumes of the presubiculum, subiculum, CA2-3, and CA4 DG compared with healthy subjects (uncorrected, P < .001). In addition, we found significant positive correlations between the presubiculum and the subicular volumes and the MMSE-K and the CERAD-K verbal delayed recall scores in the AD group.CONCLUSIONS: We are unaware of previous imaging studies of automated hippocampal subfield segmentation in AD. These structural changes in the hippocampal presubiculum, subiculum, and CA2-3 might be at the core of underlying neurobiologic mechanisms of hippocampal dysfunction and their relevance to verbal delayed recall impairments in AD.