Household Transmission of 2009 Influenza A (H1N1) Virus after a School-Based Outbreak in New York City, April-May 2009
Household Transmission of 2009 Influenza A (H1N1) Virus after a School-Based Outbreak in New York City, April-May 2009
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DOI：
10.1086/651145
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发表时间：
2010-04-01
影响因子：
6.4
通讯作者：
Hadler, James
中科院分区：
文献类型：
--
作者：
France, Anne Marie;Jackson, Michael;Hadler, James
2009年4月，在纽约市一所高中调查了2009年大流行性甲型H1N1流感病毒（pH1N1）感染引起的疫情。我们调查了患病学生的家庭接触者，以确定家庭内传播的程度，确定疾病风险最高的接触人群，并评估预防家庭传播的潜力。702名家庭接触者中有79人报告了流感样疾病（ILI）（发病率为11.3%）。多变量分析表明，年龄越大，ILI的风险就越低，年龄每增加一岁，ILI的风险就降低5%。其他保护性因素包括抗病毒预防和进行过关于流感的家庭讨论。在父母和兄弟姐妹中，为索引病例患者提供护理和与索引病例患者一起看电视分别是危险因素。50%的病例发生在学生发病后3天内。这些因素对减轻pH1N1传播的影响有影响。
In April 2009, an outbreak due to infection with the 2009 pandemic influenza A (H1N1) virus (pH1N1) was investigated in a New York City high school. We surveyed household contacts of ill students to characterize the extent of transmission within households, identify contact groups at highest risk for illness, and assess the potential for preventing household transmission. Influenza-like illness (ILI) was reported by 79 of 702 household contacts (11.3% attack rate). Multivariate analysis showed that older age was protective: for each increasing year of age, the risk of ILI was reduced 5%. Additional protective factors included antiviral prophylaxis and having had a household discussion about influenza. Providing care for the index case patient and watching television with the index case patient were risk factors among parents and siblings, respectively. Fifty percent of cases occurred within 3 days of onset of illness in the student. These factors have implications for mitigating the impact of pH1N1 transmission.