Familial risk for lung cancer by histology and age of onset: Evidence for recessive inheritance
Familial risk for lung cancer by histology and age of onset: Evidence for recessive inheritance
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DOI：
10.1080/01902140490495606
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发表时间：
2005-03-01
影响因子：
1.7
通讯作者：
Li, XJ
中科院分区：
文献类型：
--
作者：
Hemminki, K;Li, XJ
作者使用瑞典家族癌症数据库来寻找肺癌遗传易感性的证据，当父母中有一方患有肺癌时，其后代患所有肺癌的家族风险增加到1.77；兄弟姐妹之间的可比风险为2.15。在年轻时，所有组织学类型的肺癌，兄弟姐妹之间的风险高于后代和父母之间的风险。目前的数据表明，68岁以下的肺癌中有1.7%是遗传性的，可能是由于高渗透隐性基因或易患烟草致癌物的基因所致。
The authors used the Swedish Family-Cancer Database to search for evidence for a genetic predisposition in lung cancer Familial risks in offspring were increased for all lung cancer to 1.77 when a parent was affected with any lung cancers; the comparable risk among siblings was 2.15. At young age, risks between siblings were higher than those between offspring and parents for all histological types of lung cancer The present data suggest that 1.7% of lung cancers up to age 68 years are heritable and probably due to a high-penetrant recessive gene or genes that predispose to tobacco carcinogens.