TIME-RESOLVED LASER-INDUCED FLUORESCENCE SPECTROSCOPY FOR ENHANCED DEMARCATION OF HUMAN ATHEROSCLEROTIC PLAQUES
TIME-RESOLVED LASER-INDUCED FLUORESCENCE SPECTROSCOPY FOR ENHANCED DEMARCATION OF HUMAN ATHEROSCLEROTIC PLAQUES
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DOI：
10.1016/1011-1344(90)85015-o
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发表时间：
1990-03-01
影响因子：
5.4
通讯作者：
SVANBERG, S
中科院分区：
文献类型：
--
作者：
ANDERSSONENGELS, S;JOHANSSON, J;SVANBERG, S
我们报告增强人类动脉粥样硬化斑块和正常血管壁之间的分界线，获得使用时间分辨检测激光诱导荧光，而不是传统的时间积分监测技术。一个倍频锁模和腔倒空的连续波染料激光器用于皮秒脉冲产生，在320 nm，和光子计数技术，用于时间分辨的信号监测从人主动脉样品在体外。影像荧光血管镜检查和光谱指导的激光消融斑块的影响。
We report on the enhanced demarcation between human atherosclerotic plaques and normal vessel wall obtained using time-resolved detection of laser-induced fluorescence rather than the customary time-integrated monitoring technique. A frequency-doubled mode-locked and cavity-dumped continuous wave dye laser was used for picosecond pulse generation, at 320 nm, and photon-counting techniques were employed for the time-resolved signal monitoring from human aorta samples in vitro. Implications for imaging fluorescence angioscopy and spectroscopic guidance in laser ablation of plaque are indicated.