Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacine: an in-vitro dynamic study
Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacine: an in-vitro dynamic study
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DOI：
10.1007/s10856-007-3188-1
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发表时间：
2008-05-01
影响因子：
3.7
通讯作者：
Mishra, Abhilasha
中科院分区：
文献类型：
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作者：
Bajpai, A. K.;Mishra, Abhilasha
制备了羧甲基纤维素（CMC）与聚丙烯酸半互穿聚合物网络（IPNs），并对其环丙沙星（Cfx）的控释潜力进行了评价。利用红外光谱分析和环境扫描电镜（ESEM）对ipn进行了表征。对包封后的药物进行了抑菌活性和化学稳定性测定。考察了不同ipn的化学组成、Cfx的负载量、释放介质的pH和温度以及外溶液中盐离子的存在等实验参数对药物释放谱的影响。根据菲克幂律方程，计算了不同组分的扩散指数n和扩散常数D。从动力学参数数据出发，试图解析Cfx释放过程的机理。
Semi-interpenetrating polymer networks (IPNs) of carboxymethyl cellulose (CMC) and polyacrylic acid were prepared and its potential for controlled release of ciprofloxacine (Cfx) was assessed. The IPNs were characterized by IR spectral analysis and Environmental scanning electron microscopy (ESEM). The entrapped drug was examined for its antibacterial activity and chemical stability. The effects of experimental parameters such as varying chemical composition of the IPNs, percent loading of Cfx, pH and temperature of release medium and presence of salt ions in outer solution were examined on the release profile of the drug. On the basis of Fick's power law equations, the diffusion exponents (n) and diffusion constant (D) were evaluated for different IPNs compositions. From the kinetic parameter data, an attempt was made to resolve the mechanism of the release process of Cfx.