Nine lives: plasticity among T helper cell subsets.

Nine lives: plasticity among T helper cell subsets.
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DOI:
10.1084/jem.20091442
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发表时间:
2009-08-03
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Locksley RM
Locksley RM
中科院分区:
其他
文献类型:
--
作者:
Locksley RM

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两种类型的辅助性T细胞(Th)亚群之间的分工,首次描述超过20年前,已经被发现的新的亚群和新的细胞因子,可以哄骗出T细胞与越来越忽视的起源亚群的冲击。虽然Th17细胞和调节性T(T reg)细胞是被广泛接受的亚群,并且正在提出其它亚群,但是它们的可塑性难以与在Th1和Th2细胞的初始描述中提出的Th亚群的定义相一致。需要更深入的分子背景来协调效应T细胞不断增加的复杂性。
The division of labor among two types of T helper (Th) subsets, first described over 20 yr ago, has been buffeted by the discovery of new subsets and new cytokines that can be coaxed out of T cells with increasing disregard for the subset of origin. Although Th17 cells and regulatory T (T reg) cells are widely accepted subsets, and others are being proposed, their plasticity is difficult to reconcile with the definitions of Th subsets as put forth in the initial description of Th1 and Th2 cells. A deeper molecular context will be required to reconcile the ever-increasing complexity of effector T cells.
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