Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy
Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy
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DOI：
10.1016/j.jconrel.2012.11.012
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发表时间：
2013-08-10
影响因子：
10.8
通讯作者：
Lee, Doo Sung
中科院分区：
文献类型：
--
作者：
Gao, Guang Hui;Li, Yi;Lee, Doo Sung
用于癌症诊断的疏水成像标记物或用于靶向治疗的药剂的递送和对释放的控制是相当感兴趣的。依赖于血管系统的增强的渗透性和保留（EPR）和癌组织中的低pH微环境的纳米尺寸的pH敏感性聚合物胶束正在成为刺激响应性靶向疗法，其可以同时将诊断剂和治疗剂释放到癌区域中。本文综述了pH敏感聚合物胶束的研究进展及其在肿瘤诊断和靶向治疗中的应用。(C)2012年爱思唯尔B。V.保留所有权利。
The delivery and control over the release of hydrophobic imaging markers for cancer diagnosis or pharmaceutical agents for targeted therapy are of considerable interest. Nano-sized pH-sensitive polymeric micelles that rely on the enhanced permeability and retention (EPR) of vasculature and the low-pH microenvironment in cancer tissue are emerging as stimuli-responsive targeted therapies that can simultaneously release diagnostic and therapeutic agents into a cancerous region. This review focuses on the developments of pH-sensitive polymeric micelles and their biomedical applications in cancer diagnosis and targeted therapy. (C) 2012 Elsevier B. V. All rights reserved.