The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies
The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies
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DOI：
10.1007/s10439-007-9363-1
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发表时间：
2007-11-01
影响因子：
3.8
通讯作者：
Yeni, Yener N.
中科院分区：
文献类型：
--
作者：
Kim, Do-Gyoon;Hunt, Christine A.;Yeni, Yener N.
椎体松质骨是椎体的主要组成部分，对椎体的结构强度和骨折风险有显著影响。我们假设椎体中松质骨特性的变异性与椎体强度相关。基于微计算机断层扫描（micro-CT）的灰度密度（GLD）、骨体积分数（BV/TV）和有限元模量（E）对小梁椎体的不同区域进行了检查，并与实验确定的椎体强度相关。松质椎体中的两组图像是根据八个人体椎体（T10-L5）的微型CT图像进行数字化准备的。一组包括一个立方体积（每个椎体1个，n = 8），其中包括椎体的最大量松质材料，但排除所有壳体材料。另一组包括椎体前部（4个区域：椎体中线的前部、中部、左侧和右侧）和后部（2个区域：左侧和右侧）的圆柱体体积（每个椎体6个，n = 48）。椎体强度与整个椎体的GLD（r（2）= 0.57，p = 0.03）和E（r（2）= 0.63，p = 0.02）以及GLD（r（2）= 0.65，p = 0.02）、BV/TV（r（2）= 0.72，p = 0.01）和E（r（2）= 0.85，P = 0.001），椎体强度随椎体分区计算的GLD、BV/TV和E的变异系数增大而降低。椎体前部的GLD、BV/TV和E值均显著小于后部。总之，这些发现支持椎体特性的区域变异性在确定整个椎体强度中的重要作用。
Cancellous centrum is a major component of the vertebral body and significantly contributes to its structural strength and fracture risk. We hypothesized that the variability of cancellous bone properties in the centrum is associated with vertebral strength. Microcomputed tomography (micro-CT)-based gray level density (GLD), bone volume fraction (BV/TV), and finite element modulus (E) were examined for different regions of the trabecular centrum and correlated with vertebral body strength determined experimentally. Two sets of images in the cancellous centrum were digitally prepared from micro-CT images of eight human vertebral bodies (T10-L5). One set included a cubic volume (1 per vertebral centrum, n = 8) in which the largest amount of cancellous material from the centrum was included but all the shell materials were excluded. The other set included cylindrical volumes (6 per vertebral centrum, n = 48) from the anterior (4 regions: front, center, left, and right of the midline of vertebra) and the posterior (2 regions: left and right) regions of the centrum. Significant positive correlations of vertebral strength with GLD (r(2) = 0.57, p = 0.03) and E (r(2) = 0.63, p = 0.02) of the whole centrum and with GLD (r(2) = 0.65, p = 0.02), BV/TV (r(2) = 0.72, p = 0.01) and E (r(2)= 0.85, p = 0.001) of the central region of the vertebral centrum were found. Vertebral strength decreased with increasing coefficient of variation of GLD, BV/TV, and E calculated from subregions of the vertebral centrum. The values of GLD, BV/TV, and E in centrum were significantly smaller for the anterior region than for the posterior region. Overall, these findings supported the significant role of regional variability of centrum properties in determining the whole vertebral strength.