THE RELATIONSHIP BETWEEN STEREOTYPY AND MEMORY IMPROVEMENT PRODUCED BY AMPHETAMINE
THE RELATIONSHIP BETWEEN STEREOTYPY AND MEMORY IMPROVEMENT PRODUCED BY AMPHETAMINE
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DOI：
10.1007/bf00427774
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
WHITE, NM
中科院分区：
文献类型：
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作者：
CARR, GD;WHITE, NM
安非他明[A]诱导的刻板印象和记忆巩固的促进可能都是通过刺激尾状核多巴胺能活动介导的。在实验1中，大鼠分别给予刺激和电击，然后给予s.c （2mg /kg）。立即测量注射后产生的刻板印象和运动活动增加的数量。48小时后，通过观察音调抑制饮酒的能力来评估音调-休克关联的保留。记忆保留程度与刻板印象的数量显著相关，但与先前测量的运动量无关。实验2将A以10 . μ g/. μ的剂量微注射到尾状核。L)及其产生同样三种行为效应的能力被检验了。这些注射增加了刻板印象和改善了潴留，但没有增加运动能力。记忆促进与刻板印象的相关性以及两者都是由尾状核内A产生的事实表明，它们可能是由相同的神经药理底物介导的，即A诱导的尾状核中多巴胺的释放。
The possibility that amphetamine[A]-induced stereotypy and facilitation of memory consolidation are both mediated by stimulated of dopaminergic activity in the caudate nucleus. In experiment 1, rats were given pairings of a tone and a shock followed by s.c. (2 mg/kg). The amount of stereotypy and increased locomotor activity produced by the injection were measured immediately. Retention of the tone-shock association was evaluated 48 h later by observing the ability of the tone to suppress drinking. The degree of retention was significantly correlated with the amount of stereotypy but not with the amount of locomotion previously measured. In experiment 2, A was microinjected into the caudate nucleus (10 .mu.g/.mu.l) and its ability to produce the same 3 behavioral effects was examined. These injections produced increased stereotypy and improved retention but no increase in locomotion. The correlation of memory facilitation with stereotypy and the fact that both were produced by intracaudate A suggest that they may be mediated by the same neuropharmacological substrate, namely A-induced release of dopamine in the caudate.