Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring.
Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring.
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母亲头发中必需的微量金属与后代神经管缺陷风险的关联。
DOI：
10.1002/bdra.23594
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ren Aiguo
中科院分区：
文献类型：
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作者：
Yan Lailai;Wang Bin;Li Zhenjiang;Liu Yaqiong;Huo Wenhua;Wang Jingyu;Li Zhiwen;Ren Aiguo
背景必需微量金属（ETM）与神经管缺陷（NTDs）的关系尚不清楚。其中一个挑战是评估妇女在怀孕早期摄入ETM的情况。我们提出了一个假设，即ETM缺乏症的妇女在其怀孕早期是与NTDs的风险升高的后代。MethodsWe招募了191名妇女NTD影响怀孕（病例组）和261名妇女谁交付健康的婴儿（对照组）。分析了在母体早期妊娠期间生长的头发切片中的9种ETM：铁（Fe）、锌（Zn）、铜（Cu）、钴（Co）、锰（Mn）、铬（Cr）、镍（Ni）、钼（Mo）和锡（Sn）。母亲的饮食习惯的信息收集questionnaire.ResultsWe观察到一个显着的下降趋势，在剂量反应关系之间的镍和钼浓度在头发和NTD的风险。锌缺乏仅与脊柱裂风险升高相关，而锡缺乏仅与无脑儿相关。头发中的Ni和Zn浓度与新鲜绿色蔬菜和新鲜水果的食用频率呈正相关，而Zn浓度也与鱼类或肉类的食用频率呈正相关。（Ni，Mo，Zn和Sn）在我们研究人群中NTD的形成中起重要作用，并且这种摄入量与母亲的饮食习惯有关。出生缺陷研究109：234-243，2017。© 2016 Wiley Periodicals，Inc.
BackgroundThe relationship between essential trace metals (ETMs) and the risk of neural tube defects (NTDs) is still unclear. One of the challenges is to evaluate the intake of ETMs of women during their early period of pregnancy. We proposed the hypothesis that an ETM deficiency in women during their early period of pregnancy is associated with an elevated risk of NTDs in offspring.MethodsWe recruited 191 women with NTD‐affected pregnancies (case group) and 261 women who delivered healthy infants (control group). Nine ETMs in hair sections grown during maternal early pregnancy were analyzed: iron (Fe), zinc (Zn), copper (Cu), cobalt (Co), manganese (Mn), chromium (Cr), nickel (Ni), molybdenum (Mo), and stannum (Sn). Information on maternal dietary habits were collected by questionnaire.ResultsWe observed a significant decreasing trend in the dose‐response relationships between the Ni and Mo concentrations in hair and NTD risks. A Zn deficiency was only associated with an elevated risk of spina bifida, and a Sn deficiency was only associated with anencephaly. The Ni and Zn concentrations in hair were positively correlated with the frequency of consumption of fresh green vegetables and fresh fruits, while the Zn concentration was also associated with fish or meat consumption.ConclusionWe concluded that maternal intakes of the four ETMs (Ni, Mo, Zn, and Sn) played an important role in the formation of NTDs in our study population, and that this intake is related to maternal dietary habits.Birth Defects Research 109:234–243, 2017.© 2016 Wiley Periodicals, Inc.