Reversible hippocampal lesions disrupt water maze performance during both recent and remote memory tests
Reversible hippocampal lesions disrupt water maze performance during both recent and remote memory tests
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DOI：
10.1101/lm.134706
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发表时间：
2006-03-01
影响因子：
2
通讯作者：
Clark, RE
中科院分区：
文献类型：
--
作者：
Broadbent, NJ;Squire, LR;Clark, RE
传统的损毁方法表明，啮齿动物海马体的损伤会损害先前在水迷宫等任务中获得的空间记忆。相比之下，使用不同的空间任务进行可逆损伤方法的研究发现，远程记忆是可以省去的。为了确定备用远程空间记忆的发现是否依赖于损毁方法，我们在水迷宫训练后立即(0天)或1个月(30天)用利多卡因可逆地灭活了海马区。在0天和30天的留存测试中，接受利多卡因注射的大鼠表现出了减退。此外，当0天组在2天后(当药物不再有效时)重新测试时，效果相反。也就是说，之前服用利多卡因的大鼠表现与对照大鼠一样好。这些发现表明，根据水迷宫的评估，啮齿类动物的海马体对最近和远程空间记忆都很重要。在海马体功能中断后，决定远程空间记忆是保留还是受损的似乎是用来评估空间记忆的任务类型，而不是用来扰乱海马体的方法。
Conventional lesion methods have shown that damage to the rodent hippocampus can impair previously acquired spatial memory in tasks Such as the water maze. In contrast, work with reversible lesion methods using a different spatial task has found remote memory to be spared. To determine whether the finding of spared remote spatial memory depends on the lesion method, we reversibly inactivated the hippocampus with lidocaine either immediately (0-DAY) or 1 mo (30-DAY) after training in a water maze. For both the 0-DAY and 30-DAY retention tests, rats that received lidocaine infusions exhibited impaired performance. In addition, when the 0-DAY group was retested 2 d later, (when the drug was no longer active), the effect was reversed. That is, rats that had previously received lidocaine performed as well as control rats did. These findings indicate that the rodent hippocampus is important for both recent and remote spatial memory, as assessed in the water maze. What determines whether remote spatial memory is preserved or impaired following disruption of hippocampal function appears to be the type of task used to assess spatial memory, not the method used to disrupt the hippocampus.