Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors.
Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors.
复制标题
SARS-CoV-2 E 蛋白的表征：序列、结构、病毒孔蛋白和抑制剂
DOI：
10.1002/pro.4075
复制
发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Meng X
中科院分区：
文献类型：
--
作者：
Cao Y;Yang R;Lee I;Zhang W;Sun J;Wang W;Meng X
COVID-19疫情是历史上最具影响力的流行病之一。了解冠状病毒（CoV）对宿主细胞的影响对于疾病治疗非常重要。SARS-CoV-2包膜蛋白（E）是一种小的结构蛋白，参与病毒生命周期的许多方面。E蛋白促进病毒的包装和繁殖，缺失该蛋白会减弱甚至消除毒力。本综述旨在通过结合SARS-CoV-2 E蛋白研究的最新进展并将其与SARS-CoV E蛋白进行比较来建立新的知识。本文对E蛋白的氨基酸序列、结构、自组装特性、病毒孔蛋白的作用机制和抑制剂进行了综述和分析。尽管SARS-CoV-2和SARS-CoV-2 E蛋白的机制在许多方面相似，但对SARS-CoV-2 E蛋白单体和寡聚体的具体研究仍然缺乏。对这种蛋白质的全面了解应促使进一步研究有效的靶向治疗措施的设计和表征。
The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The SARS‐CoV‐2 envelope (E) protein is a small structural protein involved in many aspects of the viral life cycle. The E protein promotes the packaging and reproduction of the virus, and deletion of this protein weakens or even abolishes the virulence. This review aims to establish new knowledge by combining recent advances in the study of the SARS‐CoV‐2 E protein and by comparing it with the SARS‐CoV E protein. The E protein amino acid sequence, structure, self‐assembly characteristics, viroporin mechanisms and inhibitors are summarized and analyzed herein. Although the mechanisms of the SARS‐CoV‐2 and SARS‐CoV E proteins are similar in many respects, specific studies on the SARS‐CoV‐2 E protein, for both monomers and oligomers, are still lacking. A comprehensive understanding of this protein should prompt further studies on the design and characterization of effective targeted therapeutic measures.
登录
查看更多内容
影响因子：
5.7
作者：
Alam, Intikhab;Kamau, Allan A.;Duarte, Carlos M.
通讯作者：
Duarte, Carlos M.
影响因子：
4.8
作者：
Brazin, Kristine N.;Mallis, Robert J.;Reinherz, Ellis L.
通讯作者：
Reinherz, Ellis L.
影响因子：
3.2
作者：
Bhowmik, Deep;Nandi, Rajat;Kumar, Diwakar
通讯作者：
Kumar, Diwakar
影响因子：
5.4
作者：
Curtis, KM;Yount, B;Baric, RS
通讯作者：
Baric, RS
影响因子：
--
作者：
Da Cruz Nizer, Waleska Stephanie;Ferraz, Ariane Coelho;De Magalhaes, Jose Carlos
通讯作者：
De Magalhaes, Jose Carlos