Molecular imprinting: An approach to “tailor-made” synthetic polymers with biomimetic functions
Molecular imprinting: An approach to “tailor-made” synthetic polymers with biomimetic functions
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分子印迹：一种具有仿生功能的“定制”合成聚合物的方法
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
J. Matsui
中科院分区：
文献类型：
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作者：
T. Takeuchi;J. Matsui
本文综述了近年来利用分子印迹技术制备具有仿生功能的合成聚合物的研究进展。分子印迹是基于模板聚合，其中聚合物是在待印迹的模板分子存在下制备的。合成的聚合物在其基质中记录模板的形状和化学性质，并表现出类似抗体和类似酶的活性。该技术最显著的优点是其简单性：可以借助分子自组装构建目标分子的互补位点，这些互补位点有望成为特定的结合/催化位点，无需复杂的合成。在这篇文章中，我们介绍了分子印迹聚合物的典型例子，并特别关注分子印迹聚合物作为人工抗体的有效性和作为底物选择性催化剂的潜力。
The recent development of synthetic polymers with biomimetic functions prepared by molecular imprinting is reviewed in this article. Molecular imprinting is based on template polymerization in which polymers are prepared in the presence of a template molecule to be imprinted. Resultant polymers record the shapes and chemical properties of the templates in their matrixes and exhibit antibody-like and enzyme-like activities. The most significant advantage of this technique is its simplicity: complementary sites for the target molecules which are expected to be specific binding/catalytic sites can be constructed with the aid of molecular self-assembly and no complicated synthesis is necessary. In this article, we present typical examples of molecularly imprinted polymers and especially focus on the effectiveness of molecular imprinted polymers as artificial antibodies and the potential as substrate-selective catalysts.