Increased blood pressure in neonates and infants whose mothers smoked during pregnancy
Increased blood pressure in neonates and infants whose mothers smoked during pregnancy
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DOI：
10.1016/s0022-3476(96)70333-5
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发表时间：
1996-06-01
影响因子：
5.1
通讯作者：
Vararigou, A
中科院分区：
文献类型：
--
作者：
Beratis, NG;Panagoulias, D;Vararigou, A
目的：为了确定母亲在怀孕期间吸烟是否与新生儿血压（BP）升高有关，研究设计：我们测量了以下几组新生儿的血压：（1）73名母亲在怀孕期间吸烟的新生儿，（2）43名母亲在怀孕早期戒烟的新生儿，（3）83名被动吸烟母亲的新生儿，（4）170名不吸烟父母的新生儿。在出生后1、24、48和72小时进行三次血压测量。结果：母亲孕期吸烟量与新生儿血压呈显著正相关。从出生后的第一个小时到第72个小时，每天吸烟15支或更多的母亲的婴儿的血压明显高于不吸烟的母亲的婴儿，而当母亲每天吸烟7到15支时，血压的增加是中等的。当母亲每天吸烟3 ~ 5支、被动吸烟或在怀孕期间戒烟时，血压与对照组相似。在4 - 9个月和12个月的复查中，每天吸烟15支或更多的母亲的婴儿的收缩压和舒张压均显著高于对照组;在12个月时，吸烟母亲的5名婴儿的血压大于年龄和性别的第95百分位数。在24个月的生活有没有显着差异，在收缩压或舒张压之间的婴儿吸烟和nonsmoking mothers.Conclusions：新生儿和婴儿的母亲在怀孕期间吸烟有一个升高的血压，这是相关的吸烟的数量，每天。每天吸烟15支或更多可能会导致婴儿期血压升高，但血压在生命的第二年恢复正常。
Objectives: To determine whether maternal smoking during pregnancy is associated with increased blood pressure (BP) in neonates.Study design: We measured BP in the following groups: (1) 73 neonates of mothers who smoked during pregnancy, (2) 43 neonates of mothers who quit smoking early during pregnancy, (3) 83 neonates of passive smoking mothers, and (4) 170 neonates of nonsmoking parents. Three BP measurements were made at 1, 24, 48, and 72 hours of life. Some of the neonates were followed for 2 years.Results: We observed a significant positive correlation between the number of cigarettes smoked by the mothers during pregnancy and the BP of the neonates. From the first to the seventy-second hour of life the BP in the infants of the mothers who smoked 15 or more cigarettes per day was significantly higher than in the infants of the nonsmoking mothers, whereas the increase in BP was intermediate when the mothers smoked 7 to 15 cigarettes per day. The BP was similar to that of the control subjects when the mothers smoked 3 to 5 cigarettes per day, were passive smokers, or quit smoking during pregnancy. On reexamination between 4 and 9 months and at 12 months, in infants of mothers who smoked 15 or more cigarettes per day both the systolic and the diastolic BP were significantly higher than in the control subjects; at 12 months 5 of the infants of mothers who smoked cigarettes had BP greater than the 95th percentile for age and gender. At 24 months of life there was no significant difference in systolic or diastolic BP between infants of smoking and nonsmoking mothers.Conclusions: Neonates and infants of mothers who smoked during pregnancy have an elevation of BP that is related to the number of cigarettes smoked per day. Smoking 15 or more cigarettes per day may cause BP elevation in infancy, but the BP returns to normal during the second year of life.