Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure.
Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure.
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心脏间碘苄胍成像对心力衰竭患者的预后价值。
DOI：
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发表时间：
1992
影响因子：
9.3
通讯作者：
A. Syrota
中科院分区：
文献类型：
--
作者：
P. Merlet;H. Valette;J. Dubois;D. Moyse;D. Duboc;P. Dove;M. Bourguignon;C. Benvenuti;A. Duval;D. Agostini;D. Loisance;A. Castaigne;A. Syrota
在90例缺血性（n = 24）或特发性（n = 66）心肌病患者（平均年龄= 52 ± 7岁）中，比较了123 I-间碘苄胍（MIBG）显像与其他无创性心脏显像指数的预后价值。患者进行了不同的测量：心脏MIBG摄取，放射性核素左心室射血分数，X线心胸比率和超声心动图M型数据。心脏MIBG摄取被评估为在静脉注射后4小时获得的胸部前视图图像上测量的心脏与纵隔活动比率。然后对患者进行了1-27个月的随访，当时10名患者接受了移植，22名患者死亡，58名患者仍然存活。来自移植患者的数据未用于分析，其中多变量逐步回归判别分析显示心脏MIBG摄取比其他指标更有效地预测存活率：H/M（p <0.0001），X线心胸比率（p = 0.0017）、超声心动图舒张末期内径（p = 0.0264）和放射性核素左心室射血分数（p = 0.0301）。此外，多变量生命表分析显示，心脏MIBG摄入也是寿命的最佳预测因素：H/M（p = 0.0001）、放射性核素左心室射血分数（p = 0.0098）和X线心胸比率（p = 0.0139）;超声心动图数据没有用。因此，心脏MIBG成像可能有助于心力衰竭患者的心脏移植决策。
The prognostic value of 123I-metaiodobenzylguanidine (MIBG) imaging was compared with that of other noninvasive cardiac imaging indices in ninety patients (mean age = 52 +/- 7 yr) suffering from either ischemic (n = 24) or idiopathic (n = 66) cardiomyopathy. Patients had different measurements taken: cardiac MIBG uptake, radionuclide left ventricular ejection fraction, x-ray cardiothoracic ratio and echographic M-Mode data. Cardiac MIBG uptake was assessed as the heart-to-mediastinum activity ratio measured on the chest anterior view image obtained 4 hr after intravenous injection. The patients then had follow-up for 1-27 mo, at which time 10 patients had transplants, 22 had died and 58 were still alive. Data from patients with transplants were not used in the analysis, in which multivariate stepwise regression discriminant analysis showed that cardiac MIBG uptake was more potent to predict survival than other indices: H/M (p less than 0.0001), x-ray cardiothoracic ratio (p = 0.0017), echographic end-diastolic diameter (p = 0.0264) and radionuclide left ventricular ejection fraction (p = 0.0301). Moreover, multivariate life table analysis showed that cardiac MIBG uptake was also the best predictor for life duration: H/M (p = 0.0001), radionuclide left ventricular ejection fraction (p = 0.0098) and x-ray cardiothoracic ratio (p = 0.0139); echographic data were not useful. Thus, cardiac MIBG imaging may be helpful for heart transplantation decision making in patients with heart failure.
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间碘苄胍作为肾上腺素能神经系统完整性和功能的指标。
DOI：
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发表时间：
1987
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Sisson,JC;Wieland,DM;Sherman,P;Mangner,TJ;Tobes,MC;JacquesJr,S
通讯作者：
JacquesJr,S
卡托普利治疗充血性心力衰竭患者临床反应和生存的决定因素。
影响因子：
4.8
作者：
Creager,MA;Faxon,DP;Halperin,JL;Melidossian,CD;McCabe,CH;Schick,EC;Ryan,TJ
通讯作者：
Ryan,TJ
摄取一抑制剂对去甲肾上腺素和间碘苄胍摄取的影响。
DOI：
--
发表时间：
1985
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Tobes,MC;JaquesJr,S;Wieland,DM;Sisson,JC
通讯作者：
Sisson,JC
Iodine-123 间碘苄胍在特发性充血性心肌病和心脏移植中的心脏成像。
DOI：
--
发表时间：
1989
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Glowniak,JV;Turner,FE;Gray,LL;Palac,RT;Lagunas-Solar,MC;Woodward,WR
通讯作者：
Woodward,WR