Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas.
Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas.
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DOI：
10.1093/jnci/77.5.1047
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发表时间：
1986-11
期刊：
影响因子：
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通讯作者：
K. Sakai;S. Mori;T. Kawamoto;S. Taniguchi;O. Kobori;Y. Morioka;T. Kuroki;K. Kano
中科院分区：
文献类型：
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作者：
K. Sakai;S. Mori;T. Kawamoto;S. Taniguchi;O. Kobori;Y. Morioka;T. Kuroki;K. Kano
本文用鼠抗人表皮生长因子（EGF）受体单克隆抗体（528IgG），对正常人胃粘膜和15例进展期胃癌组织进行了EGF受体的免疫组织化学研究。正常胃粘膜仅壁细胞呈阳性染色。在15例癌组织中，9例观察到明确的染色。它们的染色强度是可变的，一般比胃壁细胞或正常扁桃体鳞状上皮弱。EGF受体染色与胃癌组织分化程度及淋巴结转移无明显相关性。
Tissues of normal human gastric mucosae and 15 advanced gastric carcinomas were studied immunohistologically for the presence of receptors for epidermal growth factor (EGF) by use of a murine monoclonal antibody (528IgG), which reacts with the binding domain of human EGF receptor. On normal gastric mucosae, only parietal cells showed positive staining. On cancer tissues, definite staining was observed in 9 of 15 cases. Their staining intensities were variable and weaker in general compared to those of either gastric parietal cells or normal tonsilar squamous epithelium. No apparent correlation of EGF receptor staining with the grade of histologic differentiation or lymph node metastases of these gastric carcinomas was noted.