Risk factors for incident herpes simplex type 2 virus infection among women attending a sexually transmitted disease clinic
Risk factors for incident herpes simplex type 2 virus infection among women attending a sexually transmitted disease clinic
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DOI：
10.1097/olq.0b013e31816fcaf8
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发表时间：
2008-07-01
影响因子：
3.1
通讯作者：
Nahmias, Andre J.
中科院分区：
文献类型：
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作者：
Gallo, Maria F.;Warner, Lee;Nahmias, Andre J.
目的：估计单纯疱疹病毒2型（HSV-2）感染的发病率，确定其获得的危险因素，并评估避孕套的保护作用。研究设计：前瞻性研究293 HSV-2血清阴性妇女，年龄18至35岁，参加性传播疾病诊所在亚拉巴马从1992年至1995年。HSV-2感染的发生率为20.5/100女性-年[95%置信区间（CI），13.1-30.5]。年轻女性（18-20岁）发生HSV-2感染的风险显著高于老年女性[校正风险比（HR），2.8; 95% CI，1.3-6.4]。诊断为流行性或偶发性细菌性阴道病的女性HSV-2感染的发生率高于未诊断的女性（校正HR，2.4; 95%CI，1.1-5.6）。没有观察到显着的保护作用，为一致的（100%）避孕套使用无破损和滑动对HSV-2收购（调整后的HR，0.8; 95% CI，0.2-2.3）。结论：收购HSV-2感染之间;研究参与者高于以前的估计为成年女性性传播疾病诊所参加者，并没有保护作用的避孕套被证明。HSV-2感染的高发病率及其潜在的不良健康后果强调了更好的预防策略的必要性。
Objectives: To estimate the incidence of herpes simplex type 2 virus (HSV-2) infection, to identify risk factors for its acquisition, and to assess the protective effect of condoms.Study Design: Prospective study of 293 HSV-2 seronegative women, aged 18 to 35 years, attending a sexually transmitted disease clinic in Alabama from 1992 to 1995.Results: Incidence of HSV-2 infection was 20.5 per 100 woman-years [95% confidence interval (CI), 13.1-30.5]. Young women (18-20 years) had a significantly higher risk of incident HSV-2 infection [adjusted hazard ratio (HR), 2.8; 95% CI, 1.3-6.4] than older women. Women diagnosed with prevalent or incident bacterial vaginosis had a higher incidence of HSV-2 infection than those who were not so diagnosed (adjusted HR, 2.4; 95% CI, 1.1-5.6). No significant protective effect was observed for consistent (100%) condom use without breakage and slippage against HSV-2 acquisition (adjusted HR, 0.8; 95% CI, 0.2-2.3).Conclusion: Acquisition of HSV-2 infection among; study participants was higher than previous estimates for adult female sexually transmitted disease clinic attendees, and no protective effect for condoms was demonstrated. The high incidence of HSV-2; infection with its potential for adverse health consequences emphasizes the need for better prevention strategies.