Chromosome sensitivity to bleomycin-induced mutagenesis, an independent risk factor for upper aerodigestive tract cancers.
Chromosome sensitivity to bleomycin-induced mutagenesis, an independent risk factor for upper aerodigestive tract cancers.
复制标题
染色体对博莱霉素诱导突变的敏感性，是上呼吸消化道癌症的独立危险因素。
作者：
M. Spitz;J. Fueger;Nancy Beddingfield;J. Annegers;T. Hsu;G. Newell;S. Schantz
缺陷的DNA修复能力，通过计数诱变剂诱导的染色体病变，可以解释变量主机易感性的环境致癌物的作用。我们比较了75例（53名男性和22名女性）既往未经治疗的上呼吸消化道恶性肿瘤患者与62名健康对照者对博莱霉素诱导的染色体损伤的敏感性。烟草和酒精使用的数据来自详细的，自我管理的癌症风险因素问卷。45例患者和13例对照对博来霉素诱导的诱变敏感（平均断裂/细胞大于0.8）。在按原发肿瘤位置分类的患者中检测到不同的敏感性。所有位点的染色体敏感性比值比均显著升高（咽癌比值比= 10.3，喉癌为8.0，口腔癌为3.8）。在logistic回归分析中，染色体敏感性在调整了年龄、性别和吸烟和饮酒的潜在混杂因素后仍然是一个强有力的独立风险因素（比值比= 4.3，95%置信限= 2.0，10.2）。尽管研究规模小，设计限制，与染色体敏感性的关联强度，即使在调整潜在的混杂因素是令人印象深刻的，并提出了一个有前途的途径，为进一步的研究。有效的致癌物敏感性标志物的预防意义是多方面的。
Defective DNA repair capability, measured by enumerating mutagen-induced chromosomal lesions, might explain variable host susceptibility to the action of environmental carcinogens. We compared sensitivity to bleomycin-induced chromosome damage in 75 patients (53 men and 22 women) with previously untreated upper aerodigestive tract malignancies with that in 62 healthy control subjects. Data on tobacco and alcohol use were derived from a detailed, self-administered cancer risk factor questionnaire. Forty-five patients and 13 controls were sensitive to bleomycin-induced mutagenesis (average breaks/cell greater than 0.8). Differential susceptibility was detected in patients categorized by primary tumor location. Odds ratios for chromosome sensitivity were significantly elevated for all sites (odds ratio = 10.3 for pharyngeal cancers, 8.0 for laryngeal cancers, and 3.8 for oral cavity cancers). On logistic regression analysis, chromosome sensitivity remained a strong and independent risk factor after adjustment for potential confounding from age, sex, and tobacco and alcohol use (odds ratio = 4.3, 95% confidence limits = 2.0, 10.2). Despite the small study size and design constraints, the strength of the association with chromosome sensitivity even after adjustment for potential confounders is impressive and suggests a promising avenue for further research. The preventive implications of a valid marker for carcinogen sensitivity are manifold.