Ferritin synthesis in normal and leukaemic leukocytes
Ferritin synthesis in normal and leukaemic leukocytes
复制标题
正常和白血病白细胞中铁蛋白的合成
作者：
G. White;M. Worwood;D. Parry;A. Jacobs
血清铁蛋白浓度通常与体内铁库1、2直接相关，但在白血病患者中也发现异常高的铁蛋白浓度3。在急性髓母细胞白血病患者中含量最高，在这种情况下，循环中白细胞内的浓度大约是正常白细胞的6倍。我们已经证明了白血病细胞中总体铁蛋白合成率异常高。以前在其他组织中的研究表明，铁蛋白的合成与铁的供应密切相关，但无论是在正常白细胞还是白血病白细胞中，铁蛋白的合成都与铁浓度无关，所形成的蛋白质几乎不含铁，如果有铁的话。
SERUM ferritin concentration is normally directly related to body iron stores1,2 but abnormally high values are also found in patients with leukaemia3. The greatest amounts are present in patients with acute myeloblastic leukaemia and in this condition the concentration within circulating leukocytes is about six times higher than in normal leukocytes4. We have demonstrated an abnormally high rate of overall ferritin synthesis in leukaemic cells. Previous studies in other tissues have shown that ferritin synthesis is closely related to iron supply, but this does not seem to be the case in either normal or leukaemic leukocytes where production of the protein is independent of iron concentration and the protein formed contains little, if any, iron.