Evidence for granulocytic incorporation of 67gallium in chronic granulocytic leukemia.
Evidence for granulocytic incorporation of 67gallium in chronic granulocytic leukemia.
复制标题
慢性粒细胞白血病中 67 镓粒细胞掺入的证据。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
George P. Canellos
中科院分区：
文献类型：
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作者：
James C. Arseneau;Roger Aamodt;Gerald S. Johnston;George P. Canellos
Abstract The studies of 67 Ga citrate uptake by leukocytes were performed in vitro and following in vivo administration. Studies in patients with chronic granulocytic leukemia (CGL) and hematologic normal subjects revealed markedly altered whole-body retention patterns in the CGL patients. This was attributable to the expanded granulocytic mass, since serial determinations in vivo of nuclide incorporation by formed elements of blood demonstrated a high affinity for granulocytes. In vitro studies confirmed marked granulocytic uptake of the nuclide compared to uptake by lymphocytes. Patients with lymphocytic leukemia failed to show an altered pattern of excretion which was correlated with minimal nuclide binding by leukemic lymphocytes studied in vitro and in vivo. Whole-body scintiscans of CGL patients consistently localized extramedullary concentrations of leukemic granulocytes. The phenomenon of 67 Ga binding by granulocytes provides a valuable method to localize disease in CGL and may prove useful in the study of granulocyte kinetics or in the clinical investigation of occult inflammatory lesions.
