Polymorphisms in candidate genes: implications for the current treatment of Parkinson’s disease
Polymorphisms in candidate genes: implications for the current treatment of Parkinson’s disease
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候选基因的多态性：对帕金森病当前治疗的影响
DOI：
10.1517/14656566.7.7.849
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发表时间：
2006
影响因子：
3.2
通讯作者：
E. Tan
中科院分区：
文献类型：
--
作者：
L. Skipper;Jian;E. Tan
药物治疗仍然是帕金森病治疗的基石。许多临床和遗传因素可能会影响治疗反应和治疗相关的并发症。一些探索性研究表明，遗传多态性可能会影响个体对多巴胺能治疗的反应以及对药物相关并发症的易感性，例如幻觉、运动障碍、运动波动和睡眠突然发作。本文对遗传多态性对帕金森病药物相关反应和并发症影响的研究的潜在效用和局限性进行了简要总结和讨论。
Pharmacological treatment remains the cornerstone of therapy in Parkinson’s disease. A number of clinical and genetic factors may influence the therapeutic response and treatment-related complications. Some exploratory studies have suggested that genetic polymorphisms may influence an individual’s response to dopaminergic therapy and susceptibility to drug-related complications, such as hallucinations, dyskinesias, motor fluctuations and sudden onset of sleep episodes. This article provides a concise summary and discussion of the potential utility and limitation of studies that have examined the influence of genetic polymorphisms on drug-related response and complications in Parkinson’s disease.