Translating gene transfer: a stalled effort.
Translating gene transfer: a stalled effort.
复制标题
翻译基因转移：一项停滞不前的努力。
DOI：
10.1111/j.1752-8062.2011.00297.x
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Windebank,AnthonyJ
中科院分区：
文献类型：
--
作者：
Greenberg,AlexandraJ;McCormick,Jennifer;Tapia,CarmenJ;Windebank,AnthonyJ
从实验室到临床的基因转移之旅一直是缓慢的，充满了许多挑战和障碍。尽管在20世纪70年代早期就有了最初的技术发展，但涉及“基因治疗”的标准临床治疗仍有待观察。此外，在20世纪90年代初，关于这项技术的文章很多，但从那以后，关于基因转移的旅程的文章就不多了。到目前为止，基因转移的转化路径，无论是陷阱还是成功，都可以作为一项研究，不仅在伦理和安全问题上，而且在科学家与公众互动的重要性上。在这里，我们研究了基因转移的转化过程，以及从它的历史中可以收集到什么。中华临床医学杂志2011；卷4:279-281
The journey of gene transfer from laboratory to clinic has been slow and fraught with many challenges and barriers. Despite the development of the initial technology in the early 1970s, a standard clinical treatment involving “gene therapy” remains to be seen. Furthermore, much was written about the technology in the early 1990s, but since then, not much has been written about the journey of gene transfer. The translational path of gene transfer thus far, both pitfalls and successes, can serve as a study not only in navigating ethical and safety concerns, but also in the importance of scientist–public interactions. Here, we examine the translational progress of gene transfer and what can be gleaned from its history. Clin Trans Sci 2011; Volume 4: 279–281