Analyzing milestones in smoking cessation: Illustration in a nicotine patch trial in adult smokers
Analyzing milestones in smoking cessation: Illustration in a nicotine patch trial in adult smokers
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DOI：
10.1037/0022-006x.74.2.276
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发表时间：
2006-04-01
影响因子：
5.9
通讯作者：
Clark, DB
中科院分区：
文献类型：
--
作者：
Shiffman, S;Scharf, DA;Clark, DB
成瘾治疗的测试很少揭示治疗在哪里发挥作用（即，促进初始戒断、预防复发和/或阻止从复发到复发的进展）。作者举例说明了在一项在成年吸烟者中进行的高剂量尼古丁贴片（35 mg; n = 188）与安慰剂（n = 136）的随机试验中对这些里程碑的区分效应的分析，这些成年吸烟者在5周治疗期间使用电子日记以真实的时间监测吸烟情况。高剂量贴剂促进了最初的戒断（风险比[HR] = 1.3），并降低了那些达到戒断的人的失戒风险（HR = 1.6）。治疗的最大效果是防止那些已经失败的人复发（HR = 7.1）。通过里程碑分析效果可以增强对戒烟治疗及其作用机制的理解。
Tests of addiction treatments seldom reveal where treatment exercises its effect (i.e., promoting initial abstinence, preventing lapses, and/or impeding progression from lapse to relapse). The authors illustrate analyses distinguishing effects on these milestones in a randomized trial of high-dose nicotine patch (35 mg; n = 188) versus placebo (n = 136) in adult smokers, who used electronic diaries to monitor smoking in real time during 5 weeks of treatment. High-dose patch promoted initial abstinence (hazard ratio [HR] = 1.3) and decreased the risk of lapsing among those who achieved abstinence (HR = 1.6). The biggest effect of treatment was to prevent progression to relapse among those who had lapsed (HR = 7.1). Analysis of effects by milestones may enhance understanding of cessation treatments and their mechanisms of action.