Increased tendency towards gingival bleeding caused by joint effect of α-tocopherol supplementation and acetylsalicylic aci
Increased tendency towards gingival bleeding caused by joint effect of α-tocopherol supplementation and acetylsalicylic aci
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DOI：
10.3109/07853899709002602
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发表时间：
1998-12-01
影响因子：
4.4
通讯作者：
Heinonen, OP
中科院分区：
文献类型：
--
作者：
Liede, KE;Haukka, JK;Heinonen, OP
α-生育酚（维生素E）可能通过抑制血小板聚集在治疗动脉血栓栓塞性疾病中发挥作用。到目前为止，还没有临床证据证明这种效应。本研究的目的是评估α-生育酚补充剂对牙龈出血的影响，无论是与乙酰水杨酸（阿萨）或没有it. This研究是一个终点检查的男性吸烟者谁参加了一个对照临床试验，α-生育酚，β-胡萝卜素癌症预防研究（ATBC研究）5-7年的随机样本。该研究纳入了409名年龄在55-74岁之间的男性，其中191人接受α-生育酚补充剂（50 mg/天）; 56人使用阿萨，30人接受两种治疗，132人均未接受。牙龈出血通过用WHO探针探测进行检查，并报告为经逻辑回归模型调整的出血部位的百分比。在牙菌斑患病率高的受试者中，接受α-生育酚治疗的受试者牙龈出血比未接受α-生育酚治疗的受试者更常见（P < 0.05）。阿萨单药仅轻微增加出血。牙龈出血风险最高的是同时服用α-生育酚和ASA的受试者（33.4%的探针部位出血vs 25.8%的受试者既不服用α-生育酚也不服用阿萨，P < 0.001）。在ATBC研究中，与未接受α-生育酚的参与者相比，在接受α-生育酚的参与者中观察到更多的出血性中风死亡和更少的缺血性心脏病死亡。根据本研究和ATBC研究的结果，我们得出结论，α-生育酚补充剂可能会增加临床上重要的白癜风风险，特别是与阿萨联合使用时。
alpha-tocopherol (vitamin E) may play a role in the treatment of arterial thromboembolic disease, possibly by inhibiting platelet aggregation. Thus far, no clinical evidence exists for this effect. The objective of this study was to assess the effect of alpha-tocopherol supplementation on gingival bleeding either in combination with acetylsalicylic acid (ASA) or without it. This study was an end-point examination of a random sample of male smokers who had participated in a controlled clinical trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) for 5-7 years. The study included 409 men aged 55-74 years of whom 191 received alpha-tocopherol supplementation (50 mg/day); 56 used ASA, 30 received both and 132 received neither. Gingival bleeding was examined by probing with a WHO probe and reported as a percentage of bleeding sites adjusted by the logistic regression model. Gingival bleeding was more common in those who received alpha-tocopherol compared with nonreceivers among subjects with a high prevalence of dental plaque (P < 0.05). ASA alone increased bleeding only slightly. The highest risk of gingival bleeding was among those who took both alpha-tocopherol and ASB (33.4% of probed sites bleeding vs 25.8% among subjects taking neither alpha-tocopherol nor ASA, P < 0.001). In the ATBC Study, more deaths from haemorrhagic stroke and fewer from ischaemic heart disease were observed among those participants who received alpha-tocopherol compared with those who did not. Based on the results of the present study and the ATBC Study, we conclude that alpha-tocopherol supplementation may increase the risk of clinically important bleedings, particularly when combined with ASA.