Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus) -: 1.: Chronic exposure
Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus) -: 1.: Chronic exposure
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DOI：
10.1016/j.cbpc.2004.09.013
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发表时间：
2004-12-01
影响因子：
2.2
通讯作者：
Buyse, J
中科院分区：
文献类型：
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作者：
Lin, H;Decuypere, E;Buyse, J
本试验研究了日粮中长期添加皮质酮（CORT）对肉鸡氧化损伤的影响。实验组肉鸡从14日龄起连续2周饲喂添加30 mg CORT/kg饲料的饲料，对照组继续饲喂对照饲料。每周记录生长性能参数，并在CORT给药前和给药后3、7和14天从两组的8只鸡中采集血样。结果表明，CORT长期给药导致蛋白质水解和脂质体生成增强。此外，CORT给药最初可能诱导活性氧（ROS）的形成，这间接反映了脂质过氧化反应的增加。然而，治疗3天后血浆尿酸（UA）和血浆铜蓝蛋白（CP）水平的显著增加表明应激期间非酶抗氧化能力的增强，并且以这种方式，减轻了更严重的氧化损伤的发展。肉鸡似乎适应高循环CORT水平的氧化还原稳态在本实验条件下治疗3天后。(C)2004爱思唯尔公司All rights reserved.
The effects of long-term dietary administration of corticosterone (CORT) on the induction of oxidative injury in broiler chickens (Gallus gallus domesticus) were evaluated. The experimental broiler chickens were fed with a diet supplemented with 30 mg CORT/kg diet for 2 weeks from 14 days of age onwards, while control chickens continued to consume the control diet. The growth performance parameters were recorded weekly, and a blood sample was obtained from eight birds of both groups before CORT administration and at 3, 7 and 14 days after treatment. The results showed that chronic CORT administration resulted in enhanced proteolysis and gluconeogenesis. Furthermore, CORT administration may initially induce the formation of reactive oxygen species (ROS) as indirectly reflected by an increase in lipid peroxidation. However, the significantly increased plasma uric acid (UA) and ceruloplasmin (CP) levels after 3 days of treatment indicates an enhancement of the nonenzymatic antioxidant capacity during stress, and in this way, the development of a more severe oxidative injury is alleviated. Broiler chickens seem to adapt to high circulating CORT levels in terms of their redox homeostasis after 3 days of treatment under the present experimental conditions. (C) 2004 Elsevier Inc. All rights reserved.