The Sec Pathways and Exportomes of Mycobacterium tuberculosis.
The Sec Pathways and Exportomes of Mycobacterium tuberculosis.
复制标题
结核分枝杆菌的 Sec 途径和输出组。
DOI：
10.1128/microbiolspec.tbtb2-0013-2016
复制
发表时间：
2017
影响因子：
3.7
通讯作者：
Braunstein,Miriam
中科院分区：
文献类型：
--
作者：
Miller,BrittanyK;Zulauf,KatelynE;Braunstein,Miriam
Approximately 20% of bacterial proteins have functions outside the cytoplasm (1). Consequently, all bacteria possess protein export pathways that transport proteins made in the cytoplasm beyond the cytoplasmic membrane. These exported proteins may remain in the bacterial cell envelope or be further secreted to the extracellular environment. Many exported proteins function in essential physiological processes. Additionally, in bacterial pathogens, many exported proteins have functions in virulence. Consequently, the pathways that export proteins are commonly essential and/or are important for pathogenesis. Across bacteria, including mycobacteria, there are conserved protein export pathways: the general secretion (Sec) and the twin‐arginine translocation (Tat) pathways. Both Sec and Tat pathways are essential to the viability ofMycobacterium tuberculosisand both also contribute to virulence (L. Rank and M. Braunstein, unpublished; 2 – 4). In addition to these conserved pathways, bacterial pathogens commonly have specialized protein export systems that are important for pathogenesis due to their role in exporting virulence factors. Mycobacteria also have specialized protein export systems: the SecA2 export pathway and five ESX (type VII) pathways. In this article, we focus on the conserved Sec pathway and the specialized SecA2 pathway, review what is known about their respective exportomes, and discuss their importance duringM. tuberculosisreplication and persistence within the host.
