Efforts to develop methods for in vivo evaluation of the native β-cell mass
Efforts to develop methods for in vivo evaluation of the native β-cell mass
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DOI：
10.1111/j.1463-1326.2008.00944.x
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发表时间：
2008-11-01
影响因子：
5.8
通讯作者：
Schneider, S.
中科院分区：
文献类型：
--
作者：
Schneider, S.
人体内天然β细胞团的可视化和定量在糖尿病自然病程的研究中以及在旨在保留糖尿病患者β细胞团的正在进行的试验中似乎很重要。这不能通过活检取样来完成，因此非常需要开发非侵入性方法。本文讨论了实现这一目标的原则理论要求。此外，它还提供了示踪探针的概述，这些探针在过去已被视为潜在的β细胞团显像剂。终于来了并对今后的发展前景进行了展望。
Visualization and quantification of the native beta-cell mass in vivo in humans appear to be important in the study of the natural course of diabetes, and in ongoing trials aimed at preserving beta-cell mass in patients with diabetes. This cannot be done by biopsy sampling, and therefore there is a great need for development of a non-invasive method. This article discusses the principle theoretical requirements for reaching this goal. In addition, it provides an overview of tracer probes, which have been examined as potential beta-cell mass imaging agents in the past. Finally. some future perspectives are discussed.