Medullospinal sympathoexcitatory neurons in normotensive and spontaneously hypertensive rats.
Medullospinal sympathoexcitatory neurons in normotensive and spontaneously hypertensive rats.
复制标题
正常血压和自发性高血压大鼠的髓脊髓交感兴奋神经元。
DOI：
10.1152/ajpregu.1986.250.5.r910
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Guyenet,PG
中科院分区：
文献类型：
--
作者：
Sun,MK;Guyenet,PG
在氟烷麻醉的 16 周龄自发性高血压大鼠 (SHR) 和正常血压 Wistar-Kyoto (WKY) 大鼠中记录主动脉降压神经放电 (AND)、腰交感神经放电 (SND) 和副巨细胞外侧核髓脊压力敏感神经元 (PGCL 神经元) 的单单位活动。研究了这些变量与平均动脉压（MAP）之间的关系。压力感受器传入的增益在不同菌株之间没有显着差异，但角 MAP（曲线线性上升部分与噪声之间的交点）在 SHR 中高出 38 mmHg。 SND 和 MAP 之间的关系以及 PGCL 神经元活动和 MAP 之间的关系的特征都是在低 MAP 处达到平台（最大活动），然后在称为截止 MAP 的水平处线性降低至零。这些曲线的平台和线性递减部分之间的理论交点被定义为角 MAP。在给定应变中，在三个级别（AND、SND、PGCL）确定的角 MAP 值是相同的，并通过 SHR 中的通用值 (38-40 mmHg) 进行重置。在 WKY 大鼠和 SHR 中，在所有三个部位测量的压力感受器反射增益（作为活动-MAP 关系的线性增量 (AND) 或减量（PGCL 和交感链）部分的斜率）是相同的。对于给定菌株，PGCL 中测量的截止 MAP 与外周交感系统中测量的截止值相同。 PGCL 神经元和腰椎 SND 的最大放电率没有显着差异，并且动脉压力感受器反馈抑制的 SND 比例没有种间差异。（摘要截断为 250 字）
Aortic depressor nerve discharge (AND), lumbar sympathetic nerve discharge (SND), and single-unit activity of medullospinal pressure-sensitive neurons of nucleus paragigantocellularis lateralis (PGCL neurons) were recorded in halothane-anesthetized 16-wk-old spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats. The relationship between these variables and mean arterial pressure (MAP) was investigated. The gain of baroreceptor afferents was not significantly different between the strains, but corner MAP (intersection between linear ascending portion of curve and noise) was 38 mmHg higher in SHRs. The relationship between SND and MAP and that between PGCL neuronal activity and MAP were both characterized by a plateau (maximal activity) at low MAP followed by a linear reduction reaching zero at a level called cutoff MAP. The theoretical intersection between the plateau and the linear decremental portion of these curves was defined as a corner MAP. Values of corner MAP determined at the three levels (AND, SND, PGCL) were identical in a given strain and reset by a common value in SHRs (38-40 mmHg). The gain of baroreceptor reflex measured at all three sites as the slope of the linear incremental (AND) or decremental (PGCL and sympathetic chain) portion of the activity-MAP relationship was the same in WKY rats and in SHRs. Cutoff MAP measured in PGCL was identical to that measured in peripheral sympathetic system for a given strain. There was no significant difference in maximal discharge rate of PGCL neurons nor in lumbar SND and no interstrain difference in the proportion of SND that was suppressible by arterial baroreceptor feedback.(ABSTRACT TRUNCATED AT 250 WORDS)