Molecular radiation biological effect in wet protein and DNA observed in the measurements of labeled electron with muons
Molecular radiation biological effect in wet protein and DNA observed in the measurements of labeled electron with muons
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DOI：
10.1016/j.physb.2008.11.237
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发表时间：
2009-04-15
影响因子：
2.8
通讯作者：
Schultz, J. S.
中科院分区：
文献类型：
--
作者：
Nagamine, K.;Torikai, E.;Schultz, J. S.
在用标记电子法对固体晶体和水溶液中的蛋白质和DNA电子转移进行的一系列实验研究中，发现含10-50%水的湿态的结果与固体形式的结果完全不同。一致的解释是通过考虑的形成和反应性的自由基，在水中产生的μ子之前，其热化。对μ子辐射效应的分子水平理解有望促进生物医学研究的进展，例如质子放射治疗癌症。(c)2008 Elsevier B. V.保留所有权利。
In a series of experimental studies of protein- and DNA-electron transfer in solid crystal and aqueous solution by the labeled electron method, the results for the wet form with 10-50% water were found to be entirely different from those for the solid form. Consistent explanations were obtained by considering the formation and reactivity of the radical that is produced in water by the muon before its thermalization. The molecular-level understandings of muon radiation effects are expected to contribute to the progress of biomedical studies, e.g. proton radiation therapy for cancer. (c) 2008 Elsevier B.V. All rights reserved.