Lactoferrin in a Context of Inflammation-Induced Pathology.
Lactoferrin in a Context of Inflammation-Induced Pathology.
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DOI：
10.3389/fimmu.2017.01438
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发表时间：
2017
影响因子：
7.3
通讯作者：
Actor JK
中科院分区：
文献类型：
--
作者：
Kruzel ML;Zimecki M;Actor JK
乳铁蛋白（LTF）是一种铁结合糖蛋白，其在免疫功能中的作用已取得了很大进展。这篇评论代表了一个独特的检查LTF对生理稳态的重要性，与疾病相关的病理学的发展。这种蛋白质的免疫调节性质来源于其独特的“感知”生物体的免疫激活状态并相应地起作用的能力。潜在的机制提出，LTF控制疾病状态，从而精确定位区域的进入LTF在维持各种生理途径，以限制组织损伤的程度。LTF作为免疫防御和对致病性和非致病性损伤的反应的第一线介质，以及对于控制氧化细胞功能至关重要的分子而被研究。LTF与其受体相互作用的机制进行了研究，重点是通过调节酶活性和活性氧产生，免疫偏离和预防细胞凋亡的保护作用。事实上，LTF作为生理稳态的关键控制点，作为与病理学相关的免疫学性能的传感器发挥作用。组织病理生理学的具体调解被描述为维持肠道完整性，在内毒素血症，引起气道炎症，由于过敏原，肺结核期间的肺损伤。最后，LTF的作用，改变适应性免疫功能的分化进行检查，其效用作为疫苗佐剂，以控制随后的淋巴细胞反应性的具体认识。总之，很明显，虽然LTF螯合铁和引导活性氧中间体的能力是减轻由于过度炎症反应引起的损伤的主要因素，但通过直接控制调节由于损伤和损伤引起的病理学的高级免疫功能的发展，进一步的作用是明显的。这在炎性损伤期间病理损伤的衰减中达到高潮。
Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-binding glycoprotein, in the milieu of immune functionality. This review represents a unique examination of LTF toward its importance in physiologic homeostasis as related to development of disease-associated pathology. The immunomodulatory nature of this protein derives from its unique ability to “sense” the immune activation status of an organism and act accordingly. Underlying mechanisms are proposed whereby LTF controls disease states, thereby pinpointing regions of entry for LTF in maintenance of various physiological pathways to limit the magnitude of tissue damage. LTF is examined as a first line mediator in immune defense and response to pathogenic and non-pathogenic injury, as well as a molecule critical for control of oxidative cell function. Mechanisms of interaction of LTF with its receptors are examined, with a focus on protective effects via regulation of enzyme activities and reactive oxygen species production, immune deviation, and prevention of cell apoptosis. Indeed, LTF serves as a critical control point in physiologic homeostasis, functioning as a sensor of immunological performance related to pathology. Specific mediation of tissue pathophysiology is described for maintenance of intestinal integrity during endotoxemia, elicited airway inflammation due to allergens, and pulmonary damage during tuberculosis. Finally, the role of LTF to alter differentiation of adaptive immune function is examined, with specific recognition of its utility as a vaccine adjuvant to control subsequent lymphocytic reactivity. Overall, it is clear that while the ability of LTF to both sequester iron and to direct reactive oxygen intermediates is a major factor in lessening damage due to excessive inflammatory responses, further effects are apparent through direct control over development of higher order immune functions that regulate pathology due to insult and injury. This culminates in attenuation of pathological damage during inflammatory injury.
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影响因子：
7.3
作者：
Cutone A;Rosa L;Lepanto MS;Scotti MJ;Berlutti F;Bonaccorsi di Patti MC;Musci G;Valenti P
通讯作者：
Valenti P
影响因子：
4.4
作者：
De la Rosa, Gonzalo;Yang, De;Oppenheim, Joost J.
通讯作者：
Oppenheim, Joost J.
影响因子：
4.5
作者：
Barber, Matthew F.;Kronenberg, Zev;Elde, Nels C.
通讯作者：
Elde, Nels C.
影响因子：
5.6
作者：
Doursout, Marie-Francoise;Horton, Haley;Kruzel, Marian L.
通讯作者：
Kruzel, Marian L.
影响因子：
4.8
作者：
Cornish, J;Callon, KE;Reid, IR
通讯作者：
Reid, IR